ABSTRACT
Genetic factors were found to play a crucial role in the development of colorectal cancer. This study was established to shed light on the possible association of HLA class-1 antigens and CRC patients, and to correlate the findings with both family history and tumor location.. Lymphocytotxicity assay has been used to assess HLA-typing of 150 blood samples of 100 CRC patients and 50 healthy normal controls in College of Dentistry/ University of Baghdad. Comparison between CRC patients and healthy controls showed several antigens, deviations in their frequencies. HLA-A2, A28 and B39 antigens were observed with increased frequencies in patient's group with significant differences [P< 0.008, 0.011 and 0.023 respectively; moreover, yet however statistical analysis showed non significant correlation of these specific HLA-Ags with both family history of CRC and tumor location. This finding demonstrated that HLA A2, A28 and B39 might play a role in CRC susceptibility