ABSTRACT
Background: Oral cancer is regarded as the sixth most common malignant tumor and is one of the leading cause of death. Lymph node metastasis is a major factor for the prognosis of oral squamous cell carcinoma [OSCC]. The objective of study was to compare the lymph node metastases with different histopathological parameters to identify high risk patients with the need for extensive treatment plans
Methods: 140 histologically proven OSCC patients visiting Ziauddin College of Dentistry were included in this study. The clinico-pathological parameters were compared by using Chi-square, Kruskal-Willis and Mann-Whitney
Results: There were 90 male and 50 female patients with 29.8% in 49-58 years age group. Buccal mucosa was the most common site of tumor. The predominant morphology of OSCC was moderately differentiated OSCC with stage IV disease. Lymph node metastasis was present in 48.6% of patients. Perineural invasion [22.9%], lymphovascular invasion [8.6%] and distant metastasis [11.1%] were also recorded. The mean tumor size was 3.45mm +/-1.95mm and mean tumor thickness was 1.8 +/-1.6mm
Conclusion: A significant association between grade, stage, tumor size, tumor thickness and distant metastasis with lymph node involvement was found. However further studies with larger sample size are required to validate these results
ABSTRACT
Despite recent advancement in pathogenesis and management of disease, oral cancer remains the most common human malignancy, worldwide. The aggressive behavior of OSCC is a challenge for new treatment modalities for primary as well as metastatic lesions. HER receptors play an important role in the normal physiological process as well as in the development of many cancers including oral squamous cell carcinoma. An electronic article search was done through PubMed, Google Scholar and Medscape were used for an electronic search of articles, using the following keywords: oral cancer, EGFR, Her/2, Her/3 and Her /4. All types of articles were included. The aim of this review is to outline the current knowledge on the role of HER receptors in the progression of OSCC in order to use them as a therapeutic target in high risk OSCC patient and to prevent them from aggressive surgeries causing post-operative morbidity