Serum level of resistin in patients with hyperthyroidism and hypothyroidism

Resistin hormone is a polypeptide hormone belonging to the family of hormone-like resistin molecules. Controversial results have been reported between serum level of resistin and thyroid abnormalities, including hypothyroidism and hyperthyroidism. The purpose of this study was to evaluate the serum level of resistin hormone in patients with hypothyroidism and hyperthyroidism and its association with weight and body mass index. In this case-control cross sectional study 48 patients with hypothyroidism, 34 patients with hyperthyroidism, and 82 individuals as control group were considered. BMI, fasting resistin, TSH, and T4 serum levels were measured by enzyme immunoassay methods. Data were compared using t-test, Pearson correlation coefficient, and ANOVA to evaluate correlation between variables. p< 0.05 was considered statistically significant. Resistin serum levels in hypothyroidism and hyperthyroidism patients was significantly higher than the control group. There was not any significant correlation between resistin serum levels, BMI, age, and thyroid hormones level. Also in hypothyroidism patients a positive correlation was observed between BMI and TSH level, and a negative correlation between BMI and T4 level. The result of this study showed the increase in serum level of resistin in patients with thyroid dysfunction. This correlation was independent of BMI changes in patient. The findings suggest that changing in serum level of resistin may be considered as a criterion for diagnosis of thyroid dysfunction. Although, this hypothesis needs to be more study

Comparative clinical trial between ciaglia and griggs techniques during tracheostomy performed in patients admitted to intensive care unit

Percutaneous dilatation tracheostomy [PDT] is one of the most frequent interventions in ventilator dependant ICU patients. Ciaglia and Griggs are two common PDT techniques. Few studies are available comparing these two methods, but there is no data available to compare these two techniques in Iranian population. The aim of this study was to compare Ciaglia and Griggs technique in our population in order to recognize advantages and disadvantages of each technique in order to identify the most beneficial one. This study is a comparative clinical trial conducted on 100 consecutive ICU admitted patients who needed prolonged intubation; half of them underwent PDT with Ciaglia method and other half with Griggs method. Procedural time and short term complications including bleeding, vital signs instability and technical errors were compared in both two methods. Both groups were comparable in demographic characteristics. Griggs method performed significantly faster than Ciaglia method [P=0.001]. Complications such as high grade bleeding [P=0.01] and cardiac dysrhythmias [P=0.07] were less in Ciaglia technique than Griggs. Skin incision smaller than required was reported more with Griggs method than Ciaglia [P=0.03]. We conclude that PDT with Ciaglia method is safer with less complications than the Griggs method. We suggest use of Ciaglia for less experienced operators.