ABSTRACT
The present study deals with the antimicrobial activity and phytochemical screening of the two medicinal plants, Tinospora cordifolia and Euphorbia hirta those are commonly available in India. Results of antimicrobial activity revealed that these medicinal plant extracts were very effective against Serratia marcescens, E. coli, Streptococcus thermophilus, Fusarium oxysporium, Aspergillus niger while these extracts showed very less inhibition against Trichoderma reesei. Phytochemical analysis of these plants confirms the presence of various phytochemical like alkaloids, flavonoids, polyphenols, steroidal terpenes in Euphorbia hirta and alkaloids, flavonoids, Saponin, tannins, steroidal terpenes, reducing sugar in Tinospora cordifolia. While other phytochemical like, glycosides, phylobatamins, xanthoproteins, phenolic compounds were found to be absent in these extracts. These plants can be a source of useful drugs but further studies are required to isolate the active component from the crude plant extract for proper drug development.