A Case of Acanthosis Nigricans Induced by Growth Hormone Therapy / 대한피부과학회지

No abstract available.

A Survey of the Awareness, Knowledge, and Vaccine Acceptability of Herpes Zoster in Dermatologic Outpatients of University Hospital / 대한피부과학회지

BACKGROUND: Herpes zoster (HZ) infection can significantly damage the quality of life of affected individuals and the treatment for HZ is lengthy and expensive. However, there is limited information available on the perception of the disease and the HZ vaccine in Korea. OBJECTIVE: The aim of this study was to determine the awareness of HZ and the HZ vaccine in patients at the dermatology clinic. METHODS: A questionnaire-based survey was conducted with 835 outpatients who visited the dermatologic clinic. RESULTS: The patient responses revealed a high level of awareness of HZ (81.2%), but a lack of detailed knowledge about HZ (56.9%) and the HZ vaccine (39.3%). As a result of this survey, it was confirmed that the level of understanding of the direct cause, pathophysiology, recurrence, and infectiousness of HZ was relatively inadequate, though there was a high level of awareness of the symptoms and clinical features of HZ in the individuals taking the questionnaire. Based on our findings, the knowledge of HZ was higher in females, the elderly, highly educated individuals, and in individuals with multiple chronic diseases (p<0.05). Additionally, the HZ vaccination rate among patients was 3.2%, and the majority of the individuals taking the questionnaire (66.2%) responded that they were willing to get vaccinated based on their physician's recommendation. CONCLUSION: Although the majority of individuals are aware of HZ, they do not appear to have sufficiently detailed knowledge about this condition. Therefore, a nationwide HZ education and vaccination program, in which dermatologists will play a major role, is strongly recommended.

Mycobacterium marinum Infection on the Face Diagnosed by Polymerase Chain Reaction Amplification and Direct Sequencing

No abstract available.

Adult Onset Dyschomatosis Universalis

No abstract available.

Rhombic Flap Reconstruction after Mohs Micrographic Surgery for Premalignant Lesions and Skin Cancer / 대한피부과학회지

BACKGROUND: Recently, increasing attention in the field of dermatological surgery has been paid to treating skin cancers, including both premalignant and malignant lesions. The rhombic flap, one of the transposition flaps, is an outstanding method for reconstructing small- to medium-sized defects after skin surgery. OBJECTIVE: The aim of this study was to evaluate our clinical results with the rhombic flap for reconstruction after Mohs micrographic surgery (MMS), including the cosmetic aspects, complete surgical excision, and recurrence. METHODS: Between June 2010 and September 2013, 37 patients who were diagnosed with premalignant and malignant lesions on the face and extremities were treated with rhombic flaps for the reconstruction of primary cutaneous defects following lesion excisions. We reviewed the medical records and evaluated the clinical aspects and surgical treatment outcomes, and the cosmetic results were scored as excellent, good, fair, or poor. In addition, we assessed the surgical treatment outcomes using the Vancouver Scar Scale (VSS). RESULTS: Thirty-seven patients received 37 rhombic flaps. The cosmetic results of the reconstructions were gratifying, and 28 of 37 patients (75.7%) showed good to excellent results. Specifically, the cosmetic results of the modified rhombic flaps were great, and 27 of 30 patients (90.0%) showed good to excellent results. The cosmetic results on the VSS showed a high mean score (2.9). CONCLUSION: Our study showed that the rhombic flap is a simple reconstruction method and provides aesthetically pleasing results. Therefore, it could be a useful option for reconstructing defects of the face and extremities.

A Clinical Study of Intralesional Immunotherapy Using Measles, Mumps, and Rubella Vaccine in Various Warts / 대한피부과학회지

BACKGROUND: Although several methods have been attempted in the treatment of warts, the traditional destructive method may be painful or ineffective and induce disfiguring scars. Therefore, a more tolerable method with fewer drawbacks is needed. OBJECTIVE: We studied the therapeutic effect of intralesional immunotherapy using the Measles, Mumps, and Rubella (MMR) vaccine and factors affecting it in patients with warts. METHODS: A retrospective study was performed in 207 patients with various types of warts, who did not meet the exclusion criteria for treatment and were followed-up from January 2011 to December 2013. Patients with warts were treated at 2-week intervals, and the therapeutic effect was evaluated 1 month after the final treatment. RESULTS: Overall, 123 (59.5%) patients experienced a greater than half reduction in the size and number of warts. In addition, younger patients (under the age of 20) (p=0.008) and those with common warts (including periungual warts) (p=0.02) showed significantly higher treatment responses. All patients complained of transient mild pain during the intralesional injections, but other side effects were rarely observed. Only 3.2% of patients who experienced a complete response had a recurrence more than 6 months after the final treatment. CONCLUSION: We suggest that intralesional immunotherapy with MMR vaccine can be considered as a primary remedy for patients who are sensitive to pain, especially children with multiple lesions, are concerned about serious side effects, or have common warts, and that treatment response will be improved by increasing the number of applications.

Milia En Plaque Showing Features of Basal Cell Carcinoma on Dermoscopic Findings / 대한피부과학회지

Dermoscopy is a noninvasive technique that is known to increase the accuracy of diagnosing benign versus malignant skin lesions. Milia en plaque is a rare benign epidermal tumor characterized by multiple milia-like lesions within the erythematous edematous base. It arises spontaneously on healthy skin in predisposed individuals without any apparent cause. An 80-year-old woman presented with a solitary coin-sized yellowish to brown plaque on the right cheek. The lesion has been enlarging for several years. Dermoscopic examination showed arborizing telangiectasia, and we suspected it to be basal cell carcinoma. Two biopsies were taken from the lesion, which revealed a keratin-filled cyst lined by a stratified epithelium of a few cell layers and sparse lymphocytic infiltration. Therefore, we diagnosed the lesion as milia en plaque, histopathologically. On the basis of our experience with a case of milia en plaque diagnosed as a basal cell carcinoma with dermoscopic findings, we believe that benign lesions should be considered even in the presence of malignant findings on dermoscopy.

A Case of Orange-Brown Chromonychia in a Patient with Kawasaki Disease

No abstract available.

Generalized Eruptive Lentiginosis in a Healthy Elderly Man

No abstract available.

Prognostic Value of HSP 70 in Colorectal Cancer

PURPOSE: To evaluate the relationships between the expression of HSP 70 and prognostic factors, including T-stage, lymph node metastasis, distant metastasis, stage, differentiation and survival rate in colorectal cancer. METHODS: We studied 62 patients with colorectal cancer in order to evaluate the relationships between the expression of HSP 70 and multiple prognostic factors, including T-stage, lymph node metastasis, distant metastasis, stage and differentiation. RESULTS: There was no statistically significant correlation among HSP 70, T-stage, lymph node metastasis, distant metastasis, stage and differentiation. However, in our study, the expression of HSP 70 was slightly elevated in case with no lymph node metastasis, a lower stage and well differentiated colorectal cancer. In regards to survival, the overall survival rate was lower in the group with positive HSP 70 vice the negative group, and this was statistically significant. CONCLUSION: HSP 70 expression and the prognostic factors of colorectal cancer appear not to be correlated to each other, although HSP 70 may play a certain role in colorectal cancer. Further studies are required for determining the prognostic factors in colorectal cancer.

The Comparative Study of Mucociliary Clearance with Long-term Hypertonic Saline versus Normal Saline Nasal Wash of Normal Person and Patients after Endoscopic Sinus Surgery / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: Nasal irrigation, a conventional therapy for both surgical and nonsurgical patients with a history of chronic rhinosinusitis, aids in the clearance of secretions, debris, and intranasal crusts. This is important in the postoperative period to reduce the risk of adhesions and to promote ostiomeatal patency. The objective of this study was to compare the effects of a long-term nasal irrigation with hypertonic saline (3.0%) versus isotonic saline (0.9%) in the normal and postoperative group. MATERIALS AND METHODS: We studied the transit time of nasal mucociliary clearance with a saccharine test. In the normal control group I (n = 20), the mean transit times (MTTs) were measured before and after the irrigation with atomized saline of 0.9%, 2%, 3%, 4% and 5% concentrations. In the normal control group Il (n=19), MTTs were measured before and after the atomized 0.9%, 3% saline irrigation for two months. In the postoperative group (n=10), MTTs were measured after the irrigation with saline of 0.9% (right nasal cavity) & 3% (left nasal cavity) for one month. The symptom scores about nasal stuffiness, rhinorrhea and the amount of nasal lavage contents were recorded daily. RESULTS: In the normal control group I, MTT of 3% saline irrigation was significantly shortened than those of isotonic and other hypertonic saline irrigation. In the normal control group II, MTT of 3% saline irrigation was gradually and significantly shortened compared with those of isotonic saline for two months. In the postoperative group, 3% saline irrigation had a significantly shorter MTT for one month and had a significantly more nasal lavage contents during 1st week than isotonic saline irrigation. CONCLUSION: A 3% hypertonic saline would be useful as a long-term nasal washing solution in both surgical and non-surgical patients with a history of chronic rhinosinusitis.

Clinical Study on Pruritus During Pregnancy

BACKGROUND: Pruritus, which is a frequent accompanying symptom of dermatological diseases, is also common during pregnancy, either localized or generalized. It may be related to specific dermatoses of pregnancy. OBJECTIVE: A clinical study was performed to know the exact nature of pruritus in pregnancy. METHODS: Subjects with systemic diseases, or laboratory abnormalities were excluded. People who have had pruritic dermatologic diseases before pregnancy were also excluded. One hundred and fifty five pregnant women were interviewed with physical examinations and followed up to the date of delivery. Pruritus was graded. RESULTS: Pruritus was present in 31.6%. Most affected subjects had mild or moderate severity. The abdomen was the most common site. There was a tendency for the duration of itching to increase with the duration of pregnancy. CONCLUSION: Conclusion: These findings may provide basic and useful data on pruritus during pregnancy.

A Clinical Study of Physiological Skin Changes in the Third Trimester of Pregnancy / 대한피부과학회지

BACKGROUND: The skin shows many physiological changes during pregnancy. Although these physiological skin changes do not usually impair the health of the mother or the fetus, some can be cosmetically significant and of importance to the dermatologist. OBJECTIVE: The aim of our study was to determine the incidence and clinical findings of these skin changes during pregnancy. METHODS: We made a prospective study of 157 women in the third trimester of pregnancy who visited the prenatal care clinic at Seoul National University Hospital from January 1996 to June 1996. Women with pathological pregnaneies were excluded. RESULTS: The results of the study are summarized as follows. 1. Various skin changes occurred such as pigmentary alteration, vascular changes, striae, abnormalities in hair growth, and nail changes. In all subjects, one or more of these changes were found. 2. The incidence of hyperpigmentation was highest among the skin changes. The incidence of hyperpigmentation of areola and nipple was 100%. Linea nigra were observed in 81.5%. 3. Palmar erythema, suprapubic hirsutism, and abdominal striae were observed in 36.3%, 14.0%, and 40.1 %, respectively. CONCLUSION: Physiological skin changes during pregnancy were various and observed with high frequency. The incidences of vascular changes, hair and nail changes in Korean pregnant women were reported for the first time.

The Effect of Ascorbic Acid , TGF - beta , and IFN - gammga on Collagen Synthesis in Three - Dimensional Culture of Normal Human Skin Fibroblast / 대한피부과학회지

BACKGROUND: The classical in vitro method for researching the fibroblast metabolism is a mono layer culture system. But there are a lot of facts that artificial influence of monolayer culture situations do not resemble the in vivo conditions. Recently three-dimensional culture method of fibroblast in collagen gel was developed and in this system fibroblasts seem to behave like in vivo situations. OBJECTIVE: So we examined the effects of ascorbic acid. TGF-beta, and IFN-gamma on fibroblast in collagen gel culture system and then compared these effects with those in monolayer culture system. We also studied the regulatory mechanism of collagen gene by ascorbic acid, TFG-beta, and IFN-gamma by Northern blot analysis in monolayer culture system. METHODS: Using fibroblasts of the neonatal foreskin, we measured the collagen synthesis after treatment of ascorbic acid, TGF-b, and IFN-r in three-dimensional culture and monolayer culture system. We aslo checked the change of mRNA of collagen after treatment in monolayer culture. RESULTS: The relative levels of collagenase-digestible protein synthesis in the three-dimensional culture seemed to be lower than those in the monolayer system. However, difference of fold in crease was not statistically significant. The expression of collagen mRNA was increased after treatment of TGF-beta and decreased after IFN-gamma treatment. CONCLUSION: From these results, fibroblasts in the three-dimensional culture system might resemble the in vivo conditions The molecular level of regulation of collagen synthesis by TGF-beta. and IFN-gamma was thought to be transcriptional. The three-dimensional culture system could be a good model of culture system of fibroblast in studying of aging process or the role of cytokine in wound healing.

A Case of Syringoma limited to the Dorsum of the Hand / 대한피부과학회지

Although syringoma is a relatively common adnexal tumor, syringoma of the hand has not been reported previously in Korea. We report a case of acral syringoma that appeared as grouped yellow-brownish papules limited to the dorsum of the right hand in a 40 year-old woman. The histopathologic findings were typical of syringoma and were characterized by the presence of numerous solid strands of basophilic epithelial cells and small cystic ducts embedded in a fibrous connective tissue stroma in the dermis. The classical "tadpole" or "comma-like tail" structures were also observed. Our case of acral syringoma presented a distinctive clinical picture, and this condition should be considered in the differential diagnosis of papular lesions of the hands.

A Case of Syringoma limited to the Dorsum of the Hand / 대한피부과학회지

Although syringoma is a relatively common adnexal tumor, syringoma of the hand has not been reported previously in Korea. We report a case of acral syringoma that appeared as grouped yellow-brownish papules limited to the dorsum of the right hand in a 40 year-old woman. The histopathologic findings were typical of syringoma and were characterized by the presence of numerous solid strands of basophilic epithelial cells and small cystic ducts embedded in a fibrous connective tissue stroma in the dermis. The classical "tadpole" or "comma-like tail" structures were also observed. Our case of acral syringoma presented a distinctive clinical picture, and this condition should be considered in the differential diagnosis of papular lesions of the hands.