Comparison of hyperbaric oxygen therapy pressures for acute carbon monoxide poisoning

Purpose@#No consensus currently exists regarding the maximal pressure of hyperbaric oxygen (HBO2) therapy performed within 24 hours of acute carbon monoxide (CO) poisoning. This study aimed to evaluate the difference in therapeutic effects according to the first HBO2 pressure (3.0 atmospheres absolute [ATA] vs. 2.8 ATA). @*Methods@#We used prospectively collected registry data on CO poisoning at a tertiary academic hospital in the Republic of Korea. Adult patients with acute CO poisoning treated with HBO2 within 24 hours after arrival at the emergency department and without the use of additional HBO2 after 24 hours between January 2007 and February 2022 were included. Data from 595 patients were analyzed using propensity score matching (PSM). Patients with mild (non-intubated) and severe (intubated) poisoning were also compared. Neurocognitive outcomes at 1 month after CO poisoning were evaluated using the Global Deterioration Scale combined with neurological impairment. @*Results@#After PSM, the neurocognitive outcomes at 1-month post-CO exposure were not significantly different between the 2.8 ATA (110 patients) and 3.0 ATA (55 patients) groups (p=1.000). Similarly, there was also no significant difference in outcomes in a subgroup analysis according to poisoning severity in matched patients (165 patients) (mild [non-intubated]: p=0.053; severe [intubated]: p=1.000). @*Conclusion@#Neurocognitive sequelae at 1 month were not significantly different between HBO2 therapy pressures of 2.8 ATA and 3.0 ATA in patients with acute CO poisoning. In addition, the 1-month neurocognitive sequelae did not differ significantly between intubated and non-intubated patients.

Comparison of Lower Extremity Muscle Function and Proprioception According to Anterior Cruciate Ligament Reconstruction in Taekwondo Demonstration Players / 대한스포츠의학회지

PURPOSE: The purpose of this study was to provide basic data for injury prevention and rehabilitation program development of Taekwondo demonstration team by comparing lower extremity muscles function and proprioceptive senses of Taekwondo demonstration team with or without anterior cruciate ligament (ACL) injury. The subjects were ACL injured Taekwondo demonstration player group (ATD, n=13) who underwent ACL reconstruction and Kukkiwon Taekwondo demonstration player group (KTD, n=13) without injury history.METHODS: To evaluate the lower extremity muscles function, we measured the flexor-extensor muscle strength ratio and isokinetic muscle strength of the knee joint using a isokinetic muscle strength measuring device. In order to investigate the proprioceptive sensory function, position sense, and threshold to detection of passive motion was using a isokinetic muscle strength measuring device. The experiment was conducted on average 26 months after surgery.RESULTS: The results of this study are as follows. There was no significant difference between the two groups in the knee joint flexor-extensor ratio. But there was a significant difference in Knee joint flexion and extension strength between two groups at an angular velocity of 60°/sec, 180°/sec, and 300°/sec. and KTD group was higher than ATD groups (p=0.014, p=0.001, p=0.029, p=0.005, p=0.043, p=0.041, respectively). There was no significant difference between the two groups in the proprioceptive sensory test.CONCLUSION: The results of this study showed that the normal flexor to extensor ratio (50%–70%), But it was close to the injury risk level. Therefore, the training program for the improvement of the muscle strength and the imbalance of the strength of the lower extremity muscle function should be performed in both groups.

The assoeiation between total cholesterol and elevated thyrotropin

BACKGROUND: Hypothyroidism may be involved in a significant portion of the causes of hypercholesterolemia in Korea. In this study, we determined the frequency of suspected hypothyroidism in hypercholesterolemic patients and compared the frequency of elevated thyrotropin levels among the groups with various total cholesterol levels. METHODS: The study subjects were healthy, asymptomatic people who visited Health Promotion Center of Seoul National University Hospital. We excluded subjects with history of hypertension, DM and hypothyroidism. The study subjects underwent physical examination and filled out a questionnaire on health risk factors. Also blood chemistry and thyroid function test were done. RESULTS: Among 6479 subjects, 194(2.99%) had elevated(>4.1 microIU/ml) thyrotropin levels. Among the hypercholesterolemic(> or=240mg/dl) patients(n=868), 40(4.60%) had elevated thyrotropin levels. And there was statistically significant difference between normal cholesterolemic and hypercholesterolemic subjects(P<0.05). Among the patients with total cholesterol above 280mg/dl (n=180), 15(8.33%) had elevated thyrotropin levels. As amount of the total cholesterol increased, the frequency of elevated thyrotropin levels Increased(P=0.001). And this result was consistent following adjustment for age, sex, BMI, smoking and drinking status(P<0.01). CONCLUSIONS: Practicing physicians should be aware of the possibility of secondary hypercholesterolemia due to hypothyroidism and keep in mind the importance of evaluating TSH level.