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Background@#Rosacea is a chronic skin inflammatory disorder that almost always occurs on the face, which can cause emotional stress and affect self-esteem. Rosacea is associated with psychiatric disorders, but there have been few studies on the relationship between rosacea and psychiatric disorders in Koreans. @*Objective@#We aimed to investigate the risk of psychiatric disorders in Korean patients with rosacea. @*Methods@#Data were obtained from the Korean National Health Insurance Service-National Sample Cohort. The database was collected according to the Korean Standard Classification of Diseases version 6, which is based on the International Classification of Diseases, 10th revision. This study was conducted with 595 patients diagnosed with rosacea from 2002 to 2013. A total of 2,380 controls were set by performing 1:4 matching for sex, age, and index year. @*Results@#The incidence of psychiatric disorders was higher in patients with rosacea (114/595, 19.16%) than in patients without rosacea (319/2,380, 13.40%), with a significant difference (p＜0.001). Among several types of psychiatric disorders, the prevalence of anxiety disorder and behavioral disorder was significantly higher in the rosacea patients than in patients without rosacea (p=0.008 and p=0.044, respectively). The adjusted hazard ratio for psychiatric disorders in patients with rosacea was 1.543 (95% confidence interval=1.238∼1.922, p＜0.001). @*Conclusion@#Rosacea is associated with many types of psychiatric disorders. Awareness of the psychological impact of rosacea might be helpful in improving patient quality of life.
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Background@#Pediatric alopecia areata (AA) can affect the quality of life (QoL) of patients and their family members. Research on the QoL and burden on family members in pediatric AA is limited. @*Objective@#This nationwide multicenter questionnaire study described the QoL and burden of the family members of patients with pediatric AA. @*Methods@#This nationwide multicenter questionnaire study enrolled AA patients between the ages of 5 and 18 years from March 1, 2017 to February 28, 2018. Enrolled patients and their parents completed the modified Children’s Dermatology Life Quality Index (CDLQI) and the modified Dermatitis Family Impact (mDFI). The disease severity was measured using the Severity of Alopecia Tool (SALT) survey scores. @*Results@#A total of 268 patients with AA from 22 hospitals participated in this study. Our study found that the efficacy and satisfaction of previous treatments of AA decreased as the severity of the disease increased. The use of home-based therapies and traditional medicines increased with the increasing severity of the disease, but the efficacy felt by patients was limited. CDLQI and mDFI scores were higher in patients with extensive AA than those with mild to moderate AA. The economic and time burden of the family members also increased as the severity of the disease increased. @*Conclusion@#The severity of the AA is indirectly proportional to the QoL of patients and their family members and directly proportional to the burden. Physicians need to understand these characteristics of pediatric AA and provide appropriate intervention to patients and their family members.
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Background@#The relationship between latent tuberculosis and the use of certain biologics is well known, but the relationship between the test for latent tuberculosis results and psoriasis itself or systemic anti-psoriatic treatment (cyclosporine and methotrexate) has not been elucidated to date. @*Objective@#To assess the influence of psoriasis and systemic anti-psoriatic treatment on results of the interferon-gamma release assay. @*Methods@#A retrospective study was conducted on 353 patients who were screened for latent tuberculosis before the use of medicines for moderate to severe psoriasis. The screening was based on results of the interferon-gamma release assay. The control group included 2,025 health care workers who were screened for latent tuberculosis during a general medical examination. @*Results@#Interferon-gamma release assay was positive in 35.4% of the patients and 11.6% of the subjects from the control group. There was a statistically significant correlation between psoriasis and assay positivity (p＜0.05). Among the patients, no statistically-relevant association regarding previous use of cyclosporine or methotrexate was found (cyclosporine: p=0.284, methotrexate: p=0.231). Furthermore, patients were divided into two groups according to treatment duration, i.e., shorter or longer than 6 months. There were no relevant differences in treatment duration cyclosporine: p=0.243, methotrexate: p=0.743). @*Conclusion@#This study revealed a higher prevalence of interferon-gamma release assay positivity in patients with psoriasis. However, conventional anti-psoriatic drugs, such as cyclosporine and methotrexate, showed no significant difference regarding the assay positivity.
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Background@#While microscopy (MS) evaluation of skin scrapings has a 100% positive predictive value and specificity by definition for scabies diagnosis, it has low sensitivity. Dermoscopy (DS) has not yet been widely accepted for diagnosis, and long-term clinician training is required. @*Objective@#To evaluate the diagnostic validity of cytochrome c oxidase subunit 1 (cox1) gene nested polymerase chain reaction (PCR) as an adjunctive method for diagnosing scabies. @*Methods@#This was a prospective, single institution study, conducted on a total of 302 skin lesions from 50 patients suspected of scabies at Kangdong Sacred Heart Hospital in Seoul, Korea. DS, MS, and cox1 nested PCR were performed on all patients. @*Results@#Of the 302 lesions, 145 (48.0%) were obtained at first visit and 157 (52.0%) were identified in the course of follow-up visits after treatment. For all lesions, DS and MS sensitivity levels were 55.9% (73/136) and 55.2% (75/136), respectively, with cox1 gene nested PCR considered as 100%. The results of DS and MS identification showed no difference between each other and showed significant difference from that of cox1 gene nested PCR. @*Conclusion@#Nested PCR detecting cox1 may be prospectively used to comprehensively diagnose lesions of scabies in clinical practice.
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Background@#While microscopy (MS) evaluation of skin scrapings has a 100% positive predictive value and specificity by definition for scabies diagnosis, it has low sensitivity. Dermoscopy (DS) has not yet been widely accepted for diagnosis, and long-term clinician training is required. @*Objective@#To evaluate the diagnostic validity of cytochrome c oxidase subunit 1 (cox1) gene nested polymerase chain reaction (PCR) as an adjunctive method for diagnosing scabies. @*Methods@#This was a prospective, single institution study, conducted on a total of 302 skin lesions from 50 patients suspected of scabies at Kangdong Sacred Heart Hospital in Seoul, Korea. DS, MS, and cox1 nested PCR were performed on all patients. @*Results@#Of the 302 lesions, 145 (48.0%) were obtained at first visit and 157 (52.0%) were identified in the course of follow-up visits after treatment. For all lesions, DS and MS sensitivity levels were 55.9% (73/136) and 55.2% (75/136), respectively, with cox1 gene nested PCR considered as 100%. The results of DS and MS identification showed no difference between each other and showed significant difference from that of cox1 gene nested PCR. @*Conclusion@#Nested PCR detecting cox1 may be prospectively used to comprehensively diagnose lesions of scabies in clinical practice.
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Background@#Erythema nodosum (EN) and erythema induratum (EI) are similar inflammatory diseases of the lower extremities. Several factors (infections, drug hypersensitivity, inflammatory diseases, etc.) have been suggested as the cause of these diseases. Among them is Mycobacterium tuberculosis (MTB) infection. However, there is still a lack of evidence supporting this finding. @*Objective@#This study aimed to confirm whether Korean patients with EN/EI will exhibit positive interferon-gamma release assay (IGRA) results and determine the association of these disease with tuberculosis. @*Methods@#We retrospectively analyzed the clinical characteristics and IGRA test results of 62 patients (46 with EN and 16 with EI). @*Results@#A total of 22 of 44 EN patients (50%) had positive IGRA test results, except for two with “undetermined” results, and 12 of 16 EI patients (75%) had positive test results. This result was higher than that of the control group (15.5%, 292/1887) and showed a statistically significant difference (each p=0.000). Moreover, the proportion of EI patients with positive test results was higher than that of patients with severe psoriasis (35.6%, 112/315; p=0.001). Among EN/EI patients with positive IGRA test results, those treated with antituberculosis therapy (HREZ) showed good response rate. The response rate was 85.7% (6/7) for patients with EN and 90% (9/10) for those with EI. @*Conclusion@#High IGRA positivity was found in Korean EN/EI patients. This finding suggests a significant association between these diseases and tuberculosis.
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Background@#Social standards for skin health have changed and have led to a rise in the general population’s interest to achieve flawless skin. @*Objective@#To survey the Korean public’s perception of skin health and dermatologists and skinhealth-related behaviors. @*Methods@#A total of 355 participants of the Skin Health Expo 2018, held by the Dermatological Research Foundation of the Korean Dermatological Association from September 14 to 16, 2018, completed a questionnaire that assessed demographics, status, and behaviors regarding skin health. The questionnaire also included lifestyle characteristics, satisfaction, behavioral factors, and perceptions regarding skin-care products. @*Results@#Participants were using various skin-care products including toners, lotions, hydrating or nutrition creams, sunscreens, essences, serums, facial masks and packs, body, hand, and foot moisturizers, eye creams, and hair products. The participants believed that the most reliable source of information on skin-care product recommendations was the dermatologist (41.55%). However, purchases were also being made at skin-care product stores (27.64%) based on the recommendation of a friend or acquaintance (40.11%). The results also revealed that 23.8% of participants experienced side effects from using skin-care and cosmetic products, and about 40% of participants could not yet distinguish hospitals run by dermatologists. @*Conclusion@#Demand for skin-care products has been increasing, and dermatologists should provide proper information about skin health to prevent adverse effects from skin-care products. Educational and informative activities, such as the expo planned by dermatologists, are necessary to improve skin health in the general population.
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No abstract available.
Subject(s)
DNA , Mycobacterium tuberculosis , Mycobacterium , Polymerase Chain Reaction , Tuberculosis , Tuberculosis, CutaneousABSTRACT
Pilomatricoma or calcifying epithelioma of Malherbe is a benign tumor originating from the matrix of hair follicles. Clinically, these tumors are classified as familial, perforating, multinodular, exophytic, anetodermic, bullous, and giant pilomatricomas. The bullous variety is observed only in 3 to 6% of cases. Furthermore, multiple pilomatricomas are rare and are usually associated with genetic disorders. To date, only 13 cases of bullous pilomatricoma and 8 cases of multiple pilomatricomas have been reported in Korean dermatologic literature. Among these cases, no case of multiple bullous pilomatricomas has been reported. This report describes a 23-year-old healthy man who was diagnosed with multiple pilomatricomas with bullous features, based on clinical and histopathological findings.
Subject(s)
Humans , Young Adult , Hair Follicle , PilomatrixomaABSTRACT
No abstract available.
Subject(s)
Myelodysplastic Syndromes , Pyoderma Gangrenosum , PyodermaABSTRACT
BACKGROUND: Plasma cell cheilitis is an unusual benign plasma cell proliferative disease of an unknown etiology that typically presents on the lip. OBJECTIVE: The aim of this study was to investigate the clinicopathological characteristics of 13 cases of plasma cell cheilitis. METHODS: The present study investigated the clinical manifestations, treatment modalities, and outcome of 13 patients diagnosed with plasma cell cheilitis from 2011 to 2016 at Kangdong Sacred Heart Hospital and Hallym University Sacred Heart Hospital. Biopsy specimens of the all cases were evaluated using conventional hematoxylin and eosin staining with kappa and lambda immunoglobulin light chain immunohistochemistry. RESULTS: The age of the patients ranged from 39 to 86 years (mean, 64.7 years), with male predominance. Histopathologically, 61.5% and 38.5% of patients showed band-like and pan dermal plasmacytic infiltrates, respectively. Eosinophilic infiltration was noted in 69.2% of patients. All cases showed both kappa and lambda immunoglobulin light chain reactivities, and kappa predominance was confirmed in 9 patients (69.2%). A majority of the patients was treated with local therapy, such as intralesional steroid injection with topical tacrolimus. Among the 13 patients, plasma cell cheilitis completely resolved, partially resolved, and recurred in 3 (23.1%), 5 (38.5%), and 5 patients (38.5%), respectively. CONCLUSION: Plasma cell cheilitis presented as erosive edematous circumscribed patches or plaques affecting mainly the lower lip of elderly male patients. The majority of histopathology cases showed characteristic plasma cell aggregation on the upper dermis that was immunopositive for immunoglobulin light chain, with kappa predominance.
Subject(s)
Aged , Humans , Male , Biopsy , Cheilitis , Dermis , Eosine Yellowish-(YS) , Eosinophils , Heart , Hematoxylin , Immunoglobulin lambda-Chains , Immunoglobulin Light Chains , Immunohistochemistry , Lip , Plasma Cells , Plasma , TacrolimusABSTRACT
BACKGROUND: Herpes zoster is characterized by unilateral grouped vesicles along the distribution of a dermatome. A global recurrence rate as low as 0.5%∼6.2% has been reported for herpes zoster. The recurrence of herpes zoster is higher in immunocompromised patients and older patients. OBJECTIVE: The purpose of this study is to assess the frequency of herpes zoster recurrence and factors that can influence its recurrence. METHODS: From January 2005 to December 2015, 14,343 patients with herpes zoster were enrolled in this study. The patients were diagnosed at Hallym University Medical Centers and Kangwon National University Hospital in Seoul, Gyeonggi, and Gangwon. Herpes zoster recurrence and patient characteristics were surveyed by medical record review and a telephonic survey. RESULTS: The overall frequency of herpes zoster recurrence was 1.18%. The frequency of recurrence was higher in women than in men. It was also higher in patients aged 50∼70 years than in patients who were younger or older than this. Additionally, we assessed that the frequency of recurrence was statistically higher in patients with a compromised immune system and in patients who experienced longer lasting pain during their first episode. CONCLUSION: The frequency of herpes zoster recurrence is more common in women, older age, patient with longer pain duration and immunocompromised patients.
Subject(s)
Female , Humans , Male , Academic Medical Centers , Herpes Zoster , Immune System , Immunocompromised Host , Korea , Medical Records , Recurrence , SeoulABSTRACT
No abstract available.