A Case of Pseudotumor of the Maxillary Sinus / 대한이비인후과학회지

Pseudotumor is a term used to describe a space occupying inflammatory lesion which mimics a true neoplastic process in its clinical presentation and radiologic findings. Its occurrence in the maxillary sinus is rare. The etiology and pathophysiology of the maxillary pseudotumor is unknown. A large and longstanding pseudotumor may induce the erosion or destruction of the maxillary bone wall. Therefore it may be difficult to distinguish such a lesion from a malignant tumor, specific granulomatous disease (e.g. tuberculosis, sarcoidosis, Wegener's granulomatosis) and fungal sinusitis preoperatively. A diagnosis of maxillary pseudotumor must be based on histological evidence to exclude other disease. We report a case of a 49-year-old patient with left maxillary pseudotumor that simulated an aggressive neoplasm in its clinical presentation and radiologic findings.

Monothermal Caloric Test: Comparison of Dizziness Sensation and Nystagmus Parameters according to Age Groups / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: here have been some studies on the influence of age on the results of vestibular function tests with conflicting results. In influence of age on the results of caloric test, we investigated the sensation of dizziness during caloric test by drawing a correlation between the direction of rotatory sensation and the direction of nystagmus. MATERIALS AND METHODS: We performed monothermal caloric test on 44 healthy adults and divided them into six age groups ranging from 16 and 67. RESULTS: During the test with eyes-closed, 80.23% of patients reported a sensation of self-rotation. Of those, 55.81% expressed the direction of rotation to be the same as that of the fast component of nystagmus, whereas 24.42% expressed the direction to be the same as that of the slow component of nystagmus. During caloric test with eyes-open in light, 59.30% reported a sensation that their surroundings rotated around them. Of those, 43.02% expressed the direction of rotatory sensation to be the same as that of the fast component of nystagmus, whereas 16.28% expressed the direction to be the same as that of the slow component of nystagmus. During caloric test with eyes-closed, most of the subjects felt themselves rotating, whereas most of the subjects felt the outside world were rotating in tests with eyes-open in the light. CONCLUSION: Nystagmus parameters (latency, duration, SPEV at eyes-open and at eyes-closed, visual suppression) did not result in significant differences among different age groups: therefore, we conclude that age doesn't influence the results of caloric tests.

Role of p53, Ras p21 and HPV Type 16, 18 on Malignant Transformaton in Inverted Papilloma of Nose and Paranasal Sinus / 대한이비인후과학회지

Mutation in p53 and p21 genes is the most common specific genetic change found in human cancers and has been investigated in a great number of neoplastic lesion. There have been some reports dealing with relationship between human papillomavirus(HPV) and papilloma associated carcinoma. But the roles of p53, ras oncoprotein and HPV have not been fully described in malignant transformation of inverted papilloma. The aim of this study was to demonstrate the mutated oncogenes immunohistochemically and evaluate relationship between expression of the oncogenes and HPV. The materials compromised 13 cases of the inverted papilloma and 6 cases associated with carcinoma. Immunohistochemical staining for p53 and ras oncogene was performed and molecular study of HPV DNA type16 and 18 was also performed with PCR on the paraffin embedded material. The carcinomatous and dysplastic areas were diffusely positive for p53 in 5 of 6 cases associated with carcinoma, whereas control group was negative for p53. And p21 immunohistochemical staining was diffusly positive in both group. A HPV DNA type 16 was negative, but type 18 was positive in 2 cases associated with carcinoma. The results indicated that p53 and HPV type 18 may be involved in pathogenesis of malignant transformation in inverted papilloma.