ABSTRACT
Vanadium is an important environmental and industrial pollutant. It has a status of reproductive toxicant and is reported to cross placental barrier. The current study was performed to assess the therapeutic efficacy of Tiron and its combination with selenium against vanadium induced toxicity in lactating and suckling rats. Rats were exposed to vanadium at a dose of 7.5 mg/kg/day [p.o.] for 20 days from 0 day of post partom [p.p.]. Tiron [606 mg/kg/day, i.p.] and selenium [0.5 mg/kg/day, p.o.] were administered for 5 days on 21-25 day PP. Vanadium exposure decreased blood sugar level while serum transaminases and serum alkaline phosphatase showed increased values significantly [p