ABSTRACT
Cerebral aspergillosis is a rare clinical condition, which is often fatal despite aggressive medical and surgical intervention. Primary central nervous system [CNS] fungal infections, where the brain is the sole site of infection in the absence of extracranial focus, are exceedingly rare. Authors report a successfully managed case of a primary solitary aspergillus brain abscess in the occipital lobe of a healthy gentleman without any previous history of medical illness. Initially, computed tomography [CT], guided stereotactic aspiration of the occipital lobe abscess, and later trephine craniotomy for the excision of the abscess with concomitant aggressive medical therapy [amphotericin-B, flucytosine] were curative. Interesting clinical, CT and operative findings are presented and discussed