ABSTRACT
1. We have shown that nonsteroidal anti-inflammatory drugs are potent inhibitors of neutrophil activation. tenoxican is a new compound of the oxican family which has been shown to be effective for routine clinical use. 2. In the present study we examined the immune pharmacological effects of this compound on lymphocyte function by determining its efffect on the expression of IL-2 receptors, on monocyte function by looking at chemotaxis and IL-1 release and on release and on neutrophil function by evaluating the chemotactic response to a standard stimulus. 3. The data show that Tenoxican inhibits the neutrophil and monocyte functional chemotactic response in vitro, and to some extent in vivo for monocytes, but has no effect onthe expression of IL-2 receptors or IL-1 release. Tenoxicam inhibits the mobilization of neutrophils and monocytes to inflamatory sites, even thought this effect was not clearly demonstrable when cells were tested after oral use
Subject(s)
Humans , In Vitro Techniques , Lymphocytes/drug effects , Monocytes/drug effects , Neutrophils , Piroxicam/analogs & derivatives , Receptors, Interleukin-2/metabolism , Chemotaxis/drug effects , Lymphocytes/metabolism , Monocytes/metabolism , Neutrophils/metabolism , Piroxicam/administration & dosage , Piroxicam/analogs & derivatives , Piroxicam/pharmacologyABSTRACT
E analisada a mortalidade infantil e pre-escolar e suas causas na cidade de Pradopolis, S.P., atraves de dados colhidos nos Cartorios de Registro Civil das cidades de Pradopolis, Guariba, Sertaozinho, Jaboticabal e Ribeirao Preto nos anos de 1977 a 1981. Os niveis baixos da mortalidade infantil registrados em 1977, 1978 e 1980, respectivamente, 15,31%, 16,39%, 12,00% e os aumentos nos anos de 1979 e 1981, respectivamente, 36,69% e 23,35% sao analisados com base na causa mortis. A mortalidade pre-escolar foi nula em todo o periodo de estudo. Ha consideracoes sobre o nivel socio-economico e a assistencia medico-social que a referida populacao recebe