ABSTRACT
Objective: The pre-eclampsia is most common hypertensive and life threatening disorder during pregnancy. Abnormal placenta may be involved in the pathogenesis of pre-eclampsia. Co-Enzyme Q10 and trace elements has been proposed as novel factors concerned in development of pre-eclampsia
Study Design: Cross sectional, comparative study
Setting: Study was conducted in Biochemistry department Liaquat University of Medical and Health Sciences Jamshoro and patients were recruited from department of Obstetrics and Gynecology Liaquat University Hospital Jamshoro / Hyderabad Duration: 1[st] February 2015 to 30[th] October 2015
Methods: Total 210 volunteers were recruited, from which 50 volunteers were normotensive healthy pregnant women as a control and 160 were pre-eclamptic patients as cases. The subjects were recruited based on sign and symptoms, taking obstetric history, anthropometric, clinical data and collecting blood sample from volunteers. The CoQ10 was evaluated on HPLC while zinc, copper and magnesium on Atomic Absorption Spectrophotometer
Results: The plasma Co-Enzyme Q10 level were found decreased in pre-eclamptic patients [mean +/-S.D] [0.22+/-0.09]micro g/dl as compared with control group[1.08+/-0.37] micro g/dl with significant difference of p<0.05. Serum zinc, copper and magnesium levels in pre-eclampsia were decreased significanlty, it was noted as [2.94+/-0.44], Cu[++] [0.19+/-0.09] and Mg[++][1.16 +/- 0.08]mg/dl as compared with normotensive women [5.09+/-0.29], [0.36+/- 0.03] and [2.15+/- 0.09] mg/dl with significant difference of p<0.05 respectively
Conclusion: The observation showed that the CoQ10 and trace elements are essential for the healthy pregnancy, declined concentration of CoQ10 and essential trace elements may put forward the possible involvement in the pathology of pre-eclampsia