Candidiasis vaginal: etiología y perfil de sensibilidad a agentes antifúngicos de uso clínico / [Vaginal candidiasis: etiology and sensitivity profile to antifungal agents in clinical use]

Candida vaginitis is one of the most frequent infection of the female genital tract with a high incidence. Approximately 75

of sexually active women suffer at least one episode of Candida vaginitis and 10

of them have recurrent episodes. Pregnancy, diabetes mellitus and antibiotic treatment are the most common predisposing factors, C. albicans is the etiologic agent most frequently found. The widespread reports of fluconazole resistance in Candida species and the selection of non Candida albicans prompted the study of species distribution of vulvovaginal candidiasis and their in vitro susceptibility against current antifungal agents. A total of 314 women with vaginal infection were studied. Yeasts were isolated from 104 patients with vulvovaginal candidiasis. The following species were identified: C. albicans 87.5

included C. krusei, C. famata, C. tropicalis and S. cerevisiae. The minimal inhibitory concentration (MIC) was determined for nystatin, isoconazole, fluconazole and ketoconazole, using a broth microdilution method based on NCCLS procedure. Although most of the isolates were C. albicans, the high percentage of C. glabrata recovered suggests the need to identify the yeasts isolated. Fluconazole resistant C. albicans were isolated in 13.46

of the cases. Thus, further studies are required to correlate the possible role of these strains in recurrent vulvovaginal candidiasis.

Flora fungica en piel lampina / Fungal floral in beardless skin

Se realizo un estudio prospectivo correspondiente a cincuenta pacientes, cuyas edades oscilaron entre catorce y setenta anos, presentando lesiones en piel lisa, compatibles con dermatomicosis. Se realizaron estudios micologicos de las muestras obtenidas, con la finalidad de conocer la flora fungica en piel lampina y la prevalencia de los distintos agentes etiologicos, causantes de dermatomicosis, segun topografia. Para los examenes directos se utilizo HOK al 20%y los aislamientos se llevaron a cabo en Agar Glucosado de Saboraud con Cloramfenicol y Agar Selectivo para Hongos Patogenos. La identificacion fue basada en observacion macroscopica microscopica y pruebas adicionales. Los estudios revelaron: 14%de levaduras pertenecientes al genero Candida, 56%de dermatofitos, no habiendose demostrado el hallazgo del genero Malasezzia. En piel lisa predomino Microsporum canis y Trichopython rubrum, en grandes pliegues lo hicieron Epidemophyton flocccosum y Candida albicans y en pequenos pliegues Trichophyton rubrum coincidiendo esto con otras estadisticas realizadas con mayor numero de casos. Se destaca el aislamiento de Microsporum gypseum como causante de dermatoficia en grandes pliegues