Fixed drug eruption due to paracetamol.

Fixed drug eruption is a common type of drug eruption seen in dermatology OPD’s. Usually it is seen with sulphonamides, salicylates, tetracyclines, oxyphenbutazones, dapsone, barbiturates, phenolphthalein, morphine, codeine, quinine, phenacetin, erythromycin, griseofulvin, mebendazole etc. We hereby report a case of fixed drug eruption due to single dose of oral paracetamol in an otherwise healthy male after one hour of consuming it. A provisional diagnosis of Paracetamol induced fixed drug eruption was made. Paracetamol was stopped and patient advised never to take Paracetamol in future. Patient was managed with prednisolone 10mg /day, cetirizine 10 mg/day, and amoxicillin 500 mg twice a day and mometasone + fusidic acid cream to be applied over the lesions.

A study of wrist ossification for age estimation in pediatric group in Central Rajasthan.

The age of ossification of different centers at wrist joint i.e. Carpals and lower ends of radius and ulna have been studied in pediatric age group in central Rajasthan. The study included 244 healthy children of both sexes up to 12 years of age. Capitate and Hamate were first (during infancy) and Pisiform (9-12 years) was last to ossify. Ossification of the 8 carpals and 2 centers for lower ends of radius and ulna respectively have a definite relation with age and can be consider as good indicator for age assessment in pediatric age group.

A study of rheumatological manifestations of leprosy.

BACKGROUND AND AIMS: Rheumatic manifestations are a common feature of leprosy. The present study was performed to assess the incidence of rheumatic manifestations in leprosy. METHODS: Seventy cases of leprosy attending the indoor and outdoor departments were studied. RESULTS: Out of the 70 cases studied, rheumatic manifestations were seen in 61.42% of cases: arthritis in 54.28% and soft tissue rheumatism in 17.14%. Enthesitis was seen in 2.84% of cases. The incidence of arthritis in lepra reactions was 57.57%. CONCLUSIONS: Musculoskeletal manifestations can occur at any time during the infection. Articular inflammation in leprosy usually occurs in reactive states, particularly erythema nodosum leprosum (ENL). Leprosy can present with arthritis as the first symptom.

Pattern of finger-prints in different ABO blood groups.

Finger print (dactylography / dermatoglyphic) is considered as the best tool of identification. This study was carried out in 2000-2001 on 300 students of different ABA blood groups of Medical College, Ajmer with two objectives, viz. (a) To study distribution of finger print pattern among the subjects having different ABO and Rh blood group and (b) Correlate any relation between their characters and blood groups. Male: female ratio was 2.4:1. Majority of the subjects (38.33%) in the study were of blood group A followed by blood group B, A and AB of whom 95.67% were Rh-positive. The general distribution of pattern of finger print showed high frequency (51.87%) of loops whereas whorls were moderate (35.83%) and arches were least (12.30%) in frequency. Almost same order was noticed in both Rh-positive and Rhnegative individuals or A, B, AB and O blood groups. Blood group A showed more loops (Rh +ve 54.26%, Rh -ve 60%) while, blood group AB had more whorls (Rh +ve 43.34%, Rh -ve60%). The study suggests an association between finger print pattern and blood group. The distribution of different pattern of finger prints in individual fingers also showed some peculiarities in relation to blood group. The total finger ridge count (TFRC) was significantly greater in blood group B.

Congenital alopecia universalis.

A case of congenital alopecia universalis without any other ectodermal defect and mental abnormality is described in a girl of eight years. There was no family history in any of the members. The child was born of a non-consanguineous marriage.

Estimation of high density lipoprotein cholesterol in the diagnosis of lepromatous leprosy.

A high incidence of increased plasma level of high density lipoprotein cholesterol (HDL-C) has been reported in cases of lepromatous leprosy. HDL-C levels were estimated in 96 (50 under treatment and 46 untreated) lepromatous leprosy patients and 84 randomly selected matched control patients suffering from other skin diseases attending skin out-patients department. HDL-C estimations were performed for the diagnosis of lepromatous leprosy in patients aged below 60 years, taking plasma HDL-C levels as 28-71 mg./dl. in men and 34-91 mg./dl. in women, as range of normal values. The study revealed that HDL-C levels in lepromatous leprosy group were raised and significantly different when compared with control group (t = 35.1668 and P less than 0.001). The sensitivity of the test was very high, 97.9 per cent (94/96), but specificity was low 80.95 per cent (68/84). False positive and false negative results were 19.04 per cent (16/84) and 2.08 per cent (2/96) respectively. It is opined that a negative test will be mainly useful in excluding diagnosis of lepromatous leprosy.