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COVID-19 pandemic is a Global burden to Public Health. An array of Neurological Manifestations have been reported to be associated with COVID-19 like Anosmia, Cerebrovascular accident, Meningitis, Encephalitis, Seizures, Guillain-Barré Syndrome (GBS), Acute Disseminated Encephalomyelitis (ADEM) etc. Generalised Myoclonus and Cerebellar Ataxia, is a less common Neurological Manifestation when compared to others. Here, we report a case of Generalized Myoclonus and Cerebellar Ataxia following COVID-19 infection. The possible mechanisms of Myoclonus and Ataxia following COVID-19 are also discussed
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Aim: The present study was undertaken to study the net photosynthetic rate (Pn), stomatal conductance (gs) and intercellular CO2 (Ci) in five eddoe and four dasheen type taro genotypes under ambient and elevated CO2 , and subjected to different photon flux densities. Methodology: The critical evaluation of Pn was assessed at different photosynthetic photon flux densities (PPFDs) viz., 200, 400, 600, 800, 1000, 1200 and 1500 µmol m-2 hr-1 under ambient CO2 (400 ppm) and at saturation PPFD (1500 µmol m-2 hr-1) at short-term (ten min) exposure of leaves to elevated CO2 (eCO2; 600, 800 and 1000 ppm) at 30oC using portable photosynthesis system LI-6400, LICOR, USA in a controlled-climate cuvette system. Results: The Pn in the leaves of nine taro genotypes persistently augmented upon short-term (10 min) exposure to eCO2 concentrations which ranged between 400 ppm and 1000 ppm. Taro genotypes exhibited 61.80 – 113.3% hike in Pn at eCO2 (1000 ppm) as compared to ambient CO2 (400 ppm). However, the per cent increase in Pn at eCO2 for every 200 ppm between 400 to1000 ppm significantly declined (4.4-18.4%) at 1000 ppm CO2. The differences in gs were statistically significant across taro genotypes (P>0.001) and CO2 concentrations (P>0.001). Further, the Ci was also found to increase constantly at eCO2 concentrations (400 ppm to 1000 ppm). However, there was significant reduction (16.2 - 31.3%) in Ci for every 200 ppm between 400-1000 ppm. Interpretation: Results of the study revealed that the genotypes Muktakeshi, Sree Pallavi and Telia are promising in the context of climate change as they significantly responded to eCO2 concentrations. Response mechanism to eCO2 need to be elucidated.
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Background: Qrbb myocardial infarction has high mortality and morbidity. So we want to study in hospital outcome of qrbbb myocardial infarction Methods: It is a prospective study. We studied qrbbb mi patients admitted in our hospital from December 2016 to June 2017 Results: About 90% of patients had heart failure. And 80% of patients required ventilatory support in the form of non–invasive positive pressure ventilation (NIPPV) or invasive ventilation. About 37% of patients had ventricular arrhythmias. Thrombolysis with streptokinase was done in 64% of patients and with tenecteplase for 20% of the patients. Percutaneous transluminal coronary angioplasty (PTCA) was done in 47% patients. Two patients had pharmacoinvasive PTCA. 16% of patients were conservatively treated due to late presentation. 24% patients died during hospital stay while 76% got discharged. 14% of patients had reversal of rbbb wave. 14% had stent thrombosis. 100% of patients had left anterior descending artery (LAD) disease. While 10% had left main coronary artery disease and 14% had triple vessel disease (TVD), 10% were sent for coronary artery bypass grafting (CABG). Conclusions: qRBBB AWMI carries high mortality of 24% with 90% of patients going in to heart failure. Ejection fraction is a good predictor of death and diabetes is a covariate of predictor of death.
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Background: Cranial mononeuropathy is a well-documented complication in people with diabetes with almost 7.5-fold increased incidence compared to the non-diabetic population. Cranial nerves III and VI appear to be involved more frequently and spontaneous recovery usually occurs within 3-6 months. Aim of the study: The present study was conducted to assess the pattern of ocular motor nerve palsy in diabetes mellitus, its correlation with glycemic control and other microvascular complications, and to study the recovery pattern. Materials and methods: 51 patients within the age group of 21-70 years with ocular motor nerve palsies who also had T2DM of any duration were included in this study. The patients underwent thorough clinical and ophthalmological examination and lab investigations and were followed up every 2-3 weeks for a period of 6 months to analyze the recovery pattern. Results: The ocular cranial nerve palsies were more common in the 51 to 60 years age group. Overall, males were affected more than females except with third nerve palsy, which showed a slight female preponderance. Sixth nerve involvement was most common and none of the patients had fourth nerve Pushpa Saravanan, R. Saravanan, P. Dharmarajan, I. Periyandavar, Rajesh Kumar Meena, Abhideep S. An observational study of ocular motor nerve palsies in diabetes mellitus. IAIM, 2019; 6(5): 73-79. Page 74 palsy. The left eye was involved more frequently. There was no significant correlation between the level of glycemic control and incidence of ocular motor nerve palsy though retinopathy and nephropathy were seen to occur more with poorer glycemic status. More than three fourth of the patients had complete or partial recovery implying a good prognosis. Conclusion: Ocular cranial nerve palsy, though a common complication of diabetes mellitus, has a good prognosis. Good glycemic control is of paramount importance for earlier and complete recovery.
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Back ground: Devastating defects are those defects where the major structures like bones, joints, nerves, and blood vessels are exposed. These defects may be due to road traffic accidents, train traffic accidents, post burn scar contracture release raw area etc. Skin grafting or simple flaps may not help in these cases making reconstruction challenge. To study the various flap options for the coverage of the elbow defects and its outcomes. Materials and methods: From the period of 2016 to 2017, all patients with elbow defects that required local or locoregional flaps were chosen for the study. Investigations included plain X-ray of the elbow. Hand held Doppler was done for patients in whom the perforator based flaps were selected for reconstruction. Results: In our study (23 patients) were males and (4 patients) were females. The most common cause was the road traffic accident (18 patients). Two patients were due to a post burn contracture release raw area. One of the patients was due to a work place accidental injury. Six patients were due to train traffic accident and of which 5 patients presented with total amputation (stump raw area). The site of the wound played a major role in determining the flap selection. In our series, most of the patients presented with defects over lateral (6 patients) and posterior lateral (7patients) elbow region. Conclusion: Meticulous planning for their construction of devastating elbow defects is necessary to achieve satisfactory results. The choice between different flaps depends on the nature of the defect, availability of donor tissues and the patient’s needs.
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A study was carried out to determine the water requirement of main crops in the perumal tank irrigation command area in Cuddalore district. The main crops include rice, groundnut, and sugarcane. The crop water requirements were determined using 15 year climatic data using CROPWAT 8.0. The seven crop growth stages (nursery,nursery/land preparation,land prepearation,initial,development,mid season,late season) and three decades (I,II,III) were considered for all crops. Crops were planted during 2012 kuruvai season and the crop coefficient was determined for each crop. Reference Crop Evapotranspiration (ETo) was determined using the FAO Penman Monteith method and the effective rainfall was calculated using USDA S.C. Method. The study shows that for the study area, reference evapotranspiration (ETo) varied from 3.67 to 6.42 mm/day and the effective rainfall varied from 12.8 to 166.8 mm. Crop evapotranspiration (ETo) and the crop water requirement for Rice varied from 0.74 mm/day to 6.23 mm/day and 0.0 mm/dec to 244 mm/dec, for groundnut 2.4 mm/day to 5.03 mm/day and 0.0 mm/dec to 29.2 mm/dec, for Rice (Navarai) 0.45 mm/day to 6.49 mm/day and 0.0 mm/dec to 152.5 mm/dec, for Groundnut (Navarai) 1.78 mm/day to 5.79 mm/day and 4.1 mm/dec to 54.8 mm/dec and for Sugarcane 2.07 mm/day to 6.57 mm/day and 0.0 mm/dec to 63.9 mm/dec respectively. The peak water requirement was 1.11 l/s/ha or 9.6 mm/day with an application efficiency of 70%.
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Background and Objectives: Leptospirosis is a potentially fatal bacterial disease that mimics many diseases; therefore, laboratory confi rmation is pivotal. Though microscopic agglutination test (MAT) is accepted as World Health Organisation (WHO) reference test, it has got many pitfalls such as being hazardous, tedious, cumbersome and expensive. Counterimmunoelectrophoresis (CIE) is popularly used for diagnosing many infectious diseases but rarely for Leptospirosis. The aim of this study is to fi nd suitability of CIE for the routine laboratory diagnostic purposes. Materials and Methods: Repeat sampling (paired sera) was possible from 401 subjects of which 181 were in-patients of Salem Government General and Private Hospitals and the remaining 220 MAT negative healthy College students gave their consent for the study. All the 802 sera samples were collected from January 2009 to November 2012 and subjected to the present study. After carrying out MAT and CIE on the suspected and control samples, a comparative evaluation was conducted. McNemars test method was used to fi nd out the signifi cant difference between the two tests in the early diagnosis. Result: The sensitivity, specifi city, Positive Predictive value (PPV), Negative Predictive value (NPV) and Effi ciency test for CIE were 96.80%, 89.28%, 95.23%, 92.59% and 94.47%, respectively. The corresponding values for MAT were 95.90%, 89.83%, 95.08%, 91.37% and 93.92%, respectively. There was no signifi cant difference between MAT and CIE at 95% and 99% confi dence intervals according to McNemars test. P value in the early stage of illness was greater for CIE than MAT when Polymerase Chain Reaction (PCR) was used as Gold Standard of diagnosis. Interpretation and conclusion: It was concluded that the CIE could be advantageous over MAT due to its safety, rapidity, simplicity, economic and easy for large number of samples. It can answer little earlier than MAT and found as reliable as that of MAT. Since both the tests had shown similar effi cacies in the later stage of the illness, the importance could be given to CIE due to early diagnosis.
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Distraction osteogenesis [DO] is a process of inducing new bone by mechanical stretching of the pre existing bone tissue. This procedure is being followed in orthopedic surgeries and orthognathic surgeries since a long time. Now a days this procedure is being applied for the orthodontic tooth movement also. This article presents a case of canine retraction with Distraction osteogenesis
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The Indian flora is extensively utilized as source of any drugs mentioned in the traditional systems of medicine. There is a continuous and urgent need to discover new antimicrobial compounds with diverse chemical structures and novel mechanisms of action for new and re-emerging infectious diseases. Therefore, researchers are increasingly turning their attention to folk medicine; looking for new leads to develop better drugs against microbial infections. The aim of the current study was to investigate antimicrobial activity of the various extracts of Calophyllum inophyllum L. An ethanol and ethyl acetate extracts of Calophyllum inophyllum L. (Family: Clusiaceae) were evaluated for antimicrobial activity against clinically important bacterial and fungal sp. The results obtained in the present study suggest that the ethanol and ethyl acetate extracts of Calophyllum inophyllum revealed a significant scope to develop a novel broad spectrum of antibacterial and antifungal herbal formulation.
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The present study was undertaken to find out the toxic effect of synthetic pyrethroid lambda cyhalothrin on the functioning of endocrine glands in freshwater catfish, Clarias batrachus.The fish were exposed to the pesticide for a period of 45 days at a sublethal concentration of 5.768 ppm. Analysis of hormone profile was carried out on the 15, 30 and 45 days of exposure to find out the alteration in hormone secretion and the response of the fish to the compound. The results obtained showed a significant decline(p<0.05) in levels of thyroid hormones and testosterone while a significant increase (p<0.05) was observed in cortisol levels during the different days of exposure of the fish to lambda cyhalothrin
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Eighteen 8-12 days old stray dog (canis familiaris mongrel) pups of either sex; 6 pups each in test groups and control group were infected with lepotspiral serovars autumnalis and canicola. The experimental animals, clinical, bacteriologic and histopathologic kinetics were observed. Both the serovars had evoked typical clinical manifestations. Leptospiraemia could be demonstratedin between the post inoculation (PI) days 1 & 5. Leptospiruria commensed in between the PI days 5 & 7 and lasted throughout the study period. Histopathologic study did not reveal any marked pathologic changes except hydropic changes in the liver of both the test groups.