Centrally mediated alpha & beta adrenoceptors controlling blood pressure in rabbits.

The effect of intracerebroventricular (icv) injection of noradrenaline (NA) on the blood pressure was studied in anaesthetised rabbits. Adrenoceptor blockers were used to study the specific adrenoceptor mediating the response. The results indicated a hypotensive response to icv injection of NA. This hypotensive response to NA was blocked by alpha-2 (yohimbine) and beta-1 (metoprolol) but not by alpha-1 (prazosin) and beta-2 (butoxamine) adrenoceptor blockers.