ABSTRACT
Objective: to study the clinico-epidemiological profile of sexually transmitted infections [STIs] among the children
Methods: it as a cross-sectional hospital-based study. Children [up to 13 years] with suspected STI were included in this study. Diagnosis of STI was done on the basis of detailed history, clinical examination and relevant laboratory investigations
Results: a total of 8,421 STI patients were seen during this period, out of which 57 were children. The commonest STI was seen in the age group of 10-13 years [71.9%]. The predominant STIs observed among these children were condyloma acuminata [genital warts] [40.3%], syphilis [14.9%], gonorrhea [13.4%], vaginal candidiasis [13.4%], herpes progenitalis [10.5%], molluscum contagiosum [6.0%] and HIV [1.5%]. In majority of cases culprits were family members
Conclusion: genital wart was the most common STI in children. Vaccination to prevent genital warts should be considered seriously
ABSTRACT
Objective: To isolate, purify, characterize, elucidate structure and evaluate bioactive compounds from the sponge-derived Salinispora sp. FS-0034. Methods: The symbiotic actinomycete strain FS-0034 with an interesting bioactivity profile was isolated from the Fijian marine sponge Theonella sp. Based on colony morphology and obligatory requirement of seawater for growth, and mycelia morphological characteristics the isolate FS-0034 was identified as a Salinispora sp. The bioactive compound was identified by using various spectral analysis of ultraviolet, high resolution electrospray ionization mass spectroscopy, 1H nuclear magnetic resonance, correlated spectroscopy and heteronuclear multiple bond coherence spectral data. A minimum inhibitory concentration assay were performed to evaluate the biological properties of the pure compound against multi-drug resistant pathogens. Results: Bioassay guided fractionation of the ethyl acetate extract of the culture of Salinispora sp. FS-0034 by different chromatographic methods yielded the isolation of an antibacterial compound, which was identified as rifamycin W (compound 1). Rifamycin W was reported for its potent antibacterial activity against methicillin-resistant Staphylococcus aureus, wild typeStaphylococcus aureus and vancomycin-resistant Enterococcus faecium and displayed minimum inhibitory concentrations of 15.62, 7.80 and 250.00 μg/mL, respectively. Conclusions:The present study reported the rifamycin W from sponge-associated Salinispora sp. and it exhibited appreciable antibacterial activity against multi-drug resistant human pathogens which indicated that sponge-associated Actinobacteria are significant sources of bioactive metabolites.