Clinical relevance of CD 10 expression in childhood acute lymphoblastic leukemia

Forty-eight patinas with a newly diagnosed acute lymphoblastic leukemia were enrolled in this study to determine the clinical relevance of CD 10 expression. CD 10 was estimated in the peripheral blood lymphoblast's using the immunofluorescent technique. The majority were between [6-10] years of age. 22 cases [45, 84%], male: female ratio equal to 1.28: 1. Most of the patients lad a moderately enlarged liver, spleen and lymph nodes, [30, 28. 22] cases [62.50% 58.34% 45, 84%] respectively. A Total white cell counts < 50.000x 10 9 /L found in 37 cases [77.08%], hemoglobin level < 8 gm / d found in 32 cases [66 67%]. and platelet counts >/= 50.000x 10'V L found in 35 cases [72.92%. FAB- L2 constitute more than half of cases, 29cases [60.42%]. CD 10 was expressed in all cases [100% with a mean and standard deviation of?4943 8.70] of these cases, 30 cases [62.50%] were of B lineage origin and 18 cases [37.50% correlation was found between CD 10 expression and the total white cell counts were of T- lineage origin. A strong significant inverse correlation was found between CD 10 expression and the age at diagnosis with a strong positive at diagnosis, Patients with T- type were older than 10 years with a higher white cell counts they fared worse than the with B-lineage leukemia which indicates that CD 10 did not have independent significance when the age and white cell counts were taken into account

Immunphentoyping of childhood acute lymphoblastic leukemia

The study was conducted a period of two years, 48 cases of newly diagnosed acute lymphoblastic leukemia were collected from the pediatric ward / oncology unit of Al- Kadlymia Teaching hospital together with 48 age and sex matched healthy children were taken as a control. The age of the patients range from 1.8-14 years. The majority were between [6-10] years 22 cases [45.85%]. 27cases [56.25%] were males and 2lcases [43.75%] females. Male: female ratio equal to 1.3:1. According to FAB morphological classification L2 constitute the majority ~29 cases [60.42%]. A white cell counts greater then 100.000/cm was encountered in the minority of cases, 5 cases only [10.41%], 3 of them were males and were more than 10 years of age. Mediastinal mass was found in 7 cases [1-4.58%] who were mainly males having FAB-L2. Immunofluorescence phenotyping of the peripheral blood lymphoblast has revealed that the patients had a higher mean percent of CD19, CDS then the control group, which is statistically highly significant [18.16+/- 5.47, 32.52+/-6.66] and [13.60+/-2.78, 19.91+/- 2.11] respectively. There was no much difference in the mean percent of CD3 and CD4 between the patients and the control group. [75.43.70, 43.2510.56] and [73.35 +/-11.55, 40.97 +/-7.77] respectively. In the patients group the mean percent of CDIO was [49.413+/-8.70], it was not done in the control group. According to this result, most of the patients had B-cell precursor leukemia, 30 cases [62.50% Followed by T-cell precursor leukemia, 18 cases [37.50 %]