ABSTRACT
In a prospective study of layered versus mass closure of abdominal incisions in infants and children, 34 cases underwent wound closure by layered and mass closure technique on an alternate basis. All the patients were assessed for their nutritional status and haemoglobin level pre-operatively, and wound complications were compared with respect to closure technique, nutritional status and normal haemoglobin level. Presence of protein energy malnutrition and anaemia did not increase the risk of wound complications with either of the technique.
Subject(s)
Abdomen/surgery , Child , Child Nutrition Disorders/complications , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Laparotomy/methods , Male , Prospective Studies , Surgical Wound Infection/epidemiology , Suture TechniquesABSTRACT
The effect of angiotensin II was studied on urine volume, urine sodium and potassium sodium and potassium in mongrel dogs. Intracerebro-ventricular (icv) administration of angiotensin (100.0 micrograms) caused significant increase in urine volume without significant change in urine sodium and potassium level. Similar effect is also obtained in denervated dogs. The effect of intracerebroventricularly administered angiotensin is possibly due to the decrease in secretion of the Antidiuretic hormone (ADH) from posterior lobe of pituitary gland.
Subject(s)
Angiotensin II/administration & dosage , Animals , Cordotomy , Diuresis/drug effects , Dogs , Female , Injections, Intraventricular , Male , Natriuresis/drug effects , Potassium/urine , Time Factors , VagotomyABSTRACT
Effect of angiotensin II was studied on blood sugar level in dogs. Angiotensins given by intravenous route caused a marked rise in blood sugar level. Indomethacin and propranolol significantly influence the changes in blood sugar level induced by angiotensin. It is suggested that the hyperglycaemia induced by angiotensin appears to be mediated by facilitation of adrenaline and prostaglandin release.
Subject(s)
Angiotensin II/administration & dosage , Animals , Blood Glucose/metabolism , Dogs , Female , Indomethacin/pharmacology , Injections, Intravenous , Male , Propranolol/pharmacology , Time FactorsABSTRACT
1. Studies were conducted on urine volume and electrolyte excretion chiefly of Na and K in anaesthetized hydrated dogs. 2. Central injection of acetylcholine caused a dose dependent antidiuretic response but without any change in excretion of urinary Sodium (UNa) and Potassium (UK). 3. After central atropinization, antidiuretic response to acetylcholine was partially blocked without any effect on electrolyte excretion. 4. Intracerebroventricularly (I.C.V.) administered acetylcholine after vagotomy and spinalectomy, each done separately and together also elicited an antidiuretic response. There was no effect on electrolyte excretion. 5. It is thus suggested that acetylcholine may be acting on central cholinergic receptors concerned with A.D.H. release.
Subject(s)
Acetylcholine/administration & dosage , Animals , Atropine/pharmacology , Depression, Chemical , Diuresis/drug effects , Dogs , Female , Injections, Intraventricular , Male , Potassium/urine , Sodium/urineABSTRACT
Actions of glucagon on the perfused vessels of the isolated rabbit ear were investigated. The two main actions of glucagon on the perfused ear vessels of the rabbit are: (i) release of noradrenaline which accounts for the constrictor response in low tone preparations. The response depends on the level of 3, 5 AMP. If the level rises as a result of noradrenaline action, contriction sets in. (ii) Glucagon may stimulate the adenylcyclase. In the high tone preparation 3,5 AMP levels are probably high. Release of noradrenaline by glucagon would have little additonal effect.