ABSTRACT
White rabbits weighing about 2kg, divided in 2 groups: the first group is administered with 5 mg, of testosterone propionate and second group administered with 50mg. The animals are killed after one, two and three weeks of administration from each group. Pituitary gland, thymus, adrenal gland and testis are removed and cut into thin preparation followed by staining with homatoxylin-eosin and van Gieson. The slides are examined microscopically and the results are as follows: 1) The chief cells and basophilic cells of anterior lobe of pituitary gland showed slight degeneration alone with vascular dilatation and congestion. s a whole, the group of massive dose revealed more severe degeneration than in the other group. 2) Thymus manifested marked congestion and severe hemorrhage, interlobular connective tissue proliferation and atrophic change in the cortex and medulla with fatty degeneration. In the group administered with massive dose, the changes are more remarkable. 3) In the adrenal gland, whole layers of cortex revealed cloudy swelling and hyaline degeneration. The cells of zona reticularis showed marked congestion. In the massive dose group, these changes are slightly more emphasized. 4) In the testis, germ cells and Sertoli cells are undergoing cloudy swelling and thickening of the basement membrane, and decreased spermatogenesis. In the group of massive dose, the changes are more prominent.