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Rev. peru. med. exp. salud publica ; 19(2): 57-62, abr.-jun. 2002. tab
Article in Spanish | LILACS, LIPECS, INS-PERU | ID: lil-493485

ABSTRACT

Objetivo: Determinar la prevalencia de marcadores serológicos para hepatitis viral B (HDV) en la población escolar de las localidades del valle del Río Pampas y evaluar el riesgo de transmisión intrafamiliar de HBV. Materiales y métodos: Esta investigación fue realizada en 8 localidades del valle del Río Pampas (Ayacucho-Andahuaylas) de marzo a noviembre de 2000 y estuvo compuesta por dos fases: En la primera fase (seroprevalencia), se seleccionó una muestra en forma aleatoria y estratificada de 130 del total de escolares registrados, quienes fueron evaluados para identificar la presencia de HBsAg, anticuerpos anti-HBcAg y anti-HDV (sólo a los HBsAg positivos). En la segunda fase (riesgo de transmisión intrafamiliar), se anidó un estudio caso-control, en el cual los casos fueron los familiares de los niños reactivos al HBsAg y los controles fueron los familiares de los escolares no reactivos (relación 1/1). En todos se evaluó la presencia de anticuerpos anti-HBcAg y HbeAg. Resultados: 18 (13.8 por ciento) escolares resultaron ser portadores de HBsAg, 93 (71.5 por ciento) tuvieron anticuerpos anti-HBcAg y 3 (16.7 por ciento) de 18 portadores de HBsAg tuvieron anticuerpos anti-HDV. No se encontró diferencias significativas en los marcadores serológicos e HBV entre los casos y controles. Conclusión: Las localidades del Valle del río Pampas (Ayacucho-Andahuylas), presentan una alta endemicidad para el HBV y una endemicidad intermedia para el HDV. No se halló riesgo de transmisión intrafamiliar.


Objective: To determine the prevalence of serum markers in infection by B (HBV) and Delta (HDV) hepatitis virus in school population of the Pampas River Valley, and to assess the risk for familiar transmission of HBV. Materials and methods: This research was carried out in eight sites in Pampas River Valley (Ayacucho-Andahuaylas) between March and November 2000, and it had two phases: in the first phase (prevalence), we selected a randomly stratified sample comprising 130 subjects from the total school population. The subjects were assessmed in order to determine the presence of HBsAg, anti HBcAg and anti-HDV antibodies (the latter test was performed only in the subjects found to be positive for HBsAg). In the second phase (familial transmission). We performed a case-control study. The cases were families of the HBsAg, reactive students and controls were families of non-HBsAg reactive students (1/1 relation). In all of them, we determinated the presence of anti-HBcAg, HBsAg, and HbeAg. Results: 18 (13.8 percentage) students were found to be HBsAg carriers, 93 (71.5 percentage) had anti-HBcAg antibodies and 3 (16.7 percentage) of the 18 HBsAg carriers had anti-HDV antibodies. There were no significant differences for the prevalence of serologic markers for HBV between cases and controls. Conclusions: The sites at Pampas River Valley (Ayacucho-Andahuaylas), have high endemicity for HBV and intermediate endemicity for HDV. No risk for familial transmission was found.


Subject(s)
Humans , Male , Adolescent , Female , Hepatitis B , Hepatitis D , Biomarkers , Prevalence , Peru
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