ABSTRACT
Nitric oxide plays a major role in increasing uterine blood flow during the luteal phase and early pregnancy. This study was done to compare uterine artery and sub-endometrial blood flow indices during the luteal phase between patients with unexplained recurrent abortion and fertile women and also to evaluate the effects of nitric oxide donors on blood flow indices in the abortion group. The study included a control group of 30 primiparae who had normal vaginal delivery and no history of abortion and an abortion group of 30 nulliparous women with history of two or more unexplained recurrent abortions. Transvaginal three-dimensional pulsed color Doppler ultrasound was done on days 21-23 of the cycle to measure uterine artery resistance and pulsation indices and the subendometrial vascular, flow and vascular-flow indices. Isosorbide mononitrate 20 mg tablet was administered vaginally in the abortion group and blood flow indices were measured again after two hours. The Student t-test and the paired t-test were used for analysis of results and a p-value of
ABSTRACT
Two groups of parturient women, each one hundred, were given either 400 ug misopristol rectally or combination of 5 IU oxytocin and 0.2 mg methergine IM for the management of the third stage of labor. Misoprostol group had shorter third stage of labor, less blood loss and post partum hemorrhage, less incidence of manual removal of the placenta and less side effects. Rectal misoprostol is safe, effective, and cheep drug for the management of the third stage of labor as a primary line of treatment or in cases in which oxytocin / methergine fail to control post partum hemorrhage