ABSTRACT
The study was carried out on 50 allergic asthmatic children in rural district in sherbin,dakahlia and received their medication and immunotherapy from clinical immunology unit,zagazig university hospital.fifty patients were divided into 40 patients as active immunotherapy group and 10 patients as control group. Immunotherapy was administered according to preseasonal schedule six month before pollen season.all patients have positive skin prick test and were evaluated clinically and immunologically pre and post immunotherapy [for six month], significant decrease in total serum IgE level P=0.018 [p<0.05] and significant increase in total serum IgG [P<0.001] after immunotherapy in all patients So immunotherapy is considered line of treatment for allergic patients