ABSTRACT
Brittenden J, Cotton SC, Elders A, Ramsey CR, Norrie J, Burr J, Campbell B, Bachoo P, Chetter I, Gough M, Earnshaw J, Lees T, Scott J, Baker SA, Francis J, Tassle E, Scotland G, Wileman S, Campbell MK. (Division of Applied Medicine, The Health Services Research Unit, and the Health Economics Research Unit, University of Aberdeen; Department of Vascular Surgery, NHS Grampian, Aberdeen Royal Infirmary, Aberdeen; School of Medicine, Medical and Biological Sciences, University of St Andrews, St Andrews; Department of Vascular Surgery, Royal Devon and Exeter Hospital, Exeter; Department of Vascular Surgery, Hull Royal Infirmary, Hull; School of Surgery, University of Leeds, and Vascular Surgery, St James University Hospital, Leeds; Vascular Surgery, Gloucestershire Royal Hospital, Gloucester; Vascular Surgery, Freeman Hospital, Newcastle upon Tyne; Vascular Surgical Unit, Royal Bournemouth Hospital, Bournemouth; and School of Health Sciences, City University London, London, UK.) A randomized trial comparing treatments for varicose veins. N Engl J Med 2014;371:1218–23.
ABSTRACT
The insulin-like activity of bis-glycinato oxovanadium (IV) complex on experimental diabetes has been studied. Rats made diabetic with streptozotocin, after one month, were fed ad libitum with bis-glycinato oxovanadium (IV) complex (30 mg/100 ml) for fifteen days. The altered blood glucose, urea, cholesterol, triglycerides, liver glycogen and the activities of liver enzymes such as hexokinase, lactate dehydrogenase and fructose-1, 6-bisphosphatase, were reverted to normal levels in bis-glycinato oxovanadium (IV) complex treated diabetic rats, thereby suggesting for the insulin-mimetic effect of bis-glycinato oxovanadium (IV) in experimental diabetes.
Subject(s)
Animals , Blood Glucose/metabolism , Diabetes Mellitus, Experimental/drug therapy , Glycine/analogs & derivatives , Insulin/pharmacology , Lipids/blood , Liver/drug effects , Male , Rats , Rats, Wistar , Vanadates/pharmacologyABSTRACT
Oral administration of sodium orthovanadate restored blood glucose to normal levels in streptozotocin-induced diabetic rats. To establish the safety dose and to evaluate the side effects of over dose, if any, different doses of vanadium were used in the present study. Low concentrations of vanadium (0·1 and 0·3 mg/ml in drinking water) restored blood glucose, urea, cholesterol and the status of liver pathophysiological enzymes to normal levels in experimental rats. High vanadate treatment proved to be toxic not only to diabetic but also to normal rats as evidenced from the observations on the blood urea, plasma and liver glutamate oxaloacetate transaminase and glutamate pyruvate transaminase. Low vanadate treatment restored body homeostasis of diabetic rats and was found to be nontoxic to normals.