ABSTRACT
To determine the relationship between premenstrual syndrome [PMS] and hematologic parameters during early follicular [EF] and late luteal [LL] phases Cross-sectional study conducted between October 2010 and February 2011 School of Nursing, Halic University, Istanbul, Turkey One hundred and eighteen healthy young women between 18 and 25 years of age None PMS status was evaluated by the Premenstrual Syndrome Scale [PMSS]. Biochemical parameters in blood were measured during EF and LL phases. More than half of the subjects demonstrated PMS [57.6%]. Leukocyte and neutrophil counts were found to be elevated during LL phase [7.24 +/- 1.67 x 103/mm3; 58.84 +/- 8.89%] compared with the EF phase [6.52 +/- 1.42 x 103/mm3; 53.81 +/- 10.76%, p < 0.001]. Class I obese group had higher PMSS scores [143 +/- 19.8] than underweight [103.92 +/- 23.54] and normal weight groups [122.62 +/- 23.54, p < 0.05]. During the LL phase, subjects with high fasting blood glucose took lower scores [11.8 +/- 3.42] from fatigue; those having low iron levels took higher scores from changes in sleeping habits [8.15 +/- 2.84] and subjects having normal and low mean corpuscular hemoglobin concentration [MCHC] levels took higher scores [13.67 +/- 4.91; 13.64 +/- 5.35] from anxiety subscales than others [p < 0.01]. Presence of elevated leukocyte value prior to menstruation suggests a relationship between menstrual cycle and inflammation. Class I obese subjects, subjects having low iron, normal fasting blood glucose and low or normal MCHC levels were found to suffer PMS-related symptoms more frequently