ABSTRACT
Lichen Planus (LP) is an inflammatory disorder of skin, mucous membranes, nails and hair. There are various modalities of treatment but none is curative. This prospective therapeutic trial was done among patients with lichen planus at the outpatient department of Dermatology & Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka between November 2001 and April 2002. Total 20 patients were taken of them 12 were male and 8 were female with male to female ratio 3:2. Age of the patients was between 10 to 50 years. Patients were diagnosed clinically & confirmed histologically. They were treated with griseofulvin 500 mg daily for 6 months. Out of 20 patients, 8 had only oral lesions, of them 2 (25%) showed complete response, 3(37.5%) showed moderate improvement and 4 (37.5%) showed no response. Other 12 patients had lichen planus involving skin without oral mucosa, of them 4 (33.3%) showed moderate improvement, 4 (33.3%) showed no response and 4 (33.3%) patients worsens with treatment. So, success in patients with cutaneous lichen planus is less likely; however, griseofulvin may afford relief in selected patients with oral lesion. This study indicates that further prospective placebo controlled studies are needed to clarify the efficacy of griseofulvin in lichen planus.
ABSTRACT
It is generally agreed that the pattern of skin diseases differs in different countries, and within various regions of a country depending on social, economic, racial and environmental factors. Many workers have reported various patterns of skin diseases in different countries. So far, no such report is available in our country for Faridpur region. To fill the lacunae we decided to undertake a retrospective study of the skin disease pattern in this tertiary hospital of Faridpur, Bangladesh. All the newly diagnosed cases attending the OPD of Dermatology and Venereology, Faridpur Medical College Hospital, during the period of one year starting from 1st July 2007 to 30th June, 2008 were included in the study. Diagnosi s was done on clinical grounds and laboratory investigations were done whenever required. Eczema (19.2%), fungal infections (17.26%), scabies (15.16%) and pyodermas (7.59%) were the major skin diseases. STD's accounted for (0.73%) of the cases. Genodermatoses (0.01%) formed the minimal number of cases. Eczema was the commonest group of disorders. Out of the infective skin disorders fungal infections were the commonest group. Genodermatoses formed the least number of cases.