ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the antioxidant activity of alcoholic leaf-extract of Solanum surattense (Solanaceae) (S. surattense).</p><p><b>METHODS</b>Leaf extract were tested for in vitro free radical scavenging assays, such as hydroxyl radical and hydrogen peroxide, inhibition of superoxide anion radical and 2, 2-diphenyl-1-picryl hydrazyl radical (DPPH), total antioxidant activity and reducing ability. Further, total phenolic content of S. surattense was analyzed.</p><p><b>RESULTS</b>S. surattense extract effectively scavenged free radicals at all different concentrations and showed its potent antioxidant activity. Further, these effects were in a dose dependent manner. Results were compared to standard antioxidants such as butylated hydroxytoluene, ascorbic acid and α-tocopherol.</p><p><b>CONCLUSIONS</b>S. surattense have strong antioxidant potential. Further the study validates the therapeutic benefits of the Indian system of medicine.</p>