Three Cases of Generalized Granuloma Annulare in Infancy Following Bacillus Calmette-Guerin Vaccination / 대한피부과학회지

Generalized granuloma annulare is a rare benign granulomatous dermatosis characterized by disseminated necrobiotic dermal papules forming an annular or nonannular configuration. It usually occurs in adults and rarely affects infants. Histologically, it presents as a lymphohistiocytic granuloma associated with varying degrees of connective tissue degeneration. Clinical associations between generalized granuloma annulare and diabetes mellitus, thyroid disease, malignancy, infection, and vaccination have been reported. There are a few cases reports of generalized granuloma annulare associated with Bacillus Calmette-Guerin (BCG) vaccination. Herein, we report three cases of generalized granuloma annulare following BCG vaccination in infants.

Idiopathic Acquired True Leukonychia Totalis and Partialis

No abstract available.

A Case of Vitiligo Associated with Paraffin Injection

No abstract available.

A Clinicopathologic Study of Thirty Cases of Acquired Perforating Dermatosis in Korea

BACKGROUND: Acquired perforating dermatosis (APD) is histopathologically characterized by transepidermal elimination of materials from the upper dermis. APD can be divided into four diseases: Kyrle's disease, perforating folliculitis, elastosis perforans serpiginosa, and reactive perforating collagenosis. APD is usually associated with systemic diseases, especially diabetes mellitus or chronic renal failure. So far, there have only been a few Korean studies of APD, which have a limited number of patients. OBJECTIVE: The aim of this study is to evaluate the clinical and histopathologic characteristics of 30 cases of APD and to examine the association with systemic diseases. METHODS: We retrospectively reviewed the medical records and biopsy specimens of 30 patients who were diagnosed with APD. RESULTS: The mean age was 55.5 years, and the average duration of the lesion was 7.8 months. The lower extremities (73.3%) were the most frequently occurring sites of the lesion. Twenty-five patients (83.3%) had pruritus, and Koebner's phenomenon was present in 11 patients. Patients of 63.3% had at least one systemic disease. Diabetes mellitus (n=17, 56.7%) and chronic renal failure (n=10, 33.3%) were the most commonly associated conditions. Most patients received topical steroids (93.3%) and antihistamines (80.0%). The most common histopathologic type was reactive perforating collagenosis (n=23, 73.3%). CONCLUSION: In this study, most patients had a systemic association to the diseases. Therefore, we suggest that further evaluation is necessary for patients who present with APD. This includes reviewing patient's comprehensive past medical history, clinical exam, and additional diagnostic testing to check for the possibility of associated systemic diseases.

Partial Unilateral Lentiginosis with an Ocular Involvement / 대한피부과학회지

Partial unilateral lentiginosis is a rare pigmentary disorder which is characterized by multiple grouped lentigines in unilateral or segmental distributions. The ocular involvement of the disease is extremely rare and only four cases have been reported until today. The exact pathophysiology is still unknown. An 18-year-old woman is being presented with unilateral hyperpigmented macules on her left forehead, eyelid, cheek, lip and chin which all demarcated sharply at the midline of her face. The lesion has been presented since the age of 1. Also, there are discrete brownish pigmentations on her left bulbar conjunctiva. Biopsy specimen is being obtained from the left chin and the histopathological examinations revealed increasing basal layer of pigmentations and mild elongation of rete ridges. The histopathological features are also consistent with lentigo simplex. Herein, we present a rare case of partial unilateral lentiginosis with an ocular involvement. We have also proposed that the partial unilateral lentiginosis has a possibility of ocular involvements.

Idiopathic Granulomatous Vulvitis / 대한피부과학회지

Granulomatous vulvitis is a rare localized inflammatory disease characterized by a painless, swollen, indurated and distorted vulva. Histopathologically, it shows chronic non-necrotizing granulomatous inflammation with edema, fibrosis, and lymphangiectasia. Some cases are associated with granulomatous cheilitis or Crohn's disease. So far, only a few cases of idiopathic granulomatous vulvitis have been reported. A 43-year-old female presented with a 1-year-history of persistent swelling of the vulva. The lesion was enlarged, edematous, and indurated, and there were clustered vesicles and papules on the labia major. Histopathologic examination of the swollen labia major showed granulomatous inflammation composed of multinucleated giant cells and epithelioid cells, with numerous lymphocytes in the dermis. Another biopsy specimen obtained from the clustered vesicles showed lymphangiectasia with chronic inflammation. Based on these characteristic histopathologic features and clinical findings, the patient was diagnosed with idiopathic granulomatous vulvitis. Herein, we reported a rare case of idiopathic granulomatous vulvitis that developed in a healthy woman.

Four Cases of Subepidermal Calcified Nodule on the Sole / 대한피부과학회지

Subepidermal calcified nodule is an unusual type of idiopathic calcinosis cutis and usually presents as an asymptomatic, solitary, firm, verrucous, white or yellowish nodule. It commonly occurs in young children, generally on the face and neck, especially eyelid, cheek. However, sole is a very rare site. Four patients presented with several months??history of solitary 2~3 mm sized firm nodule on the sole. Three of the patients were less than 1 year old, with no history of trauma. Histopathologic examination revealed hyperkeratosis, acanthosis and amorphous basophilic material in cystic space beneath the epidermis, meaning deposition of calcium salt. These histopathologic features were consistent with subepidermal calcified nodule. Serum calcium and phosphorus levels of the patients were within normal limits. Herein, we present 4 cases of subepidermal calcified nodule on the sole, an atypical location.

Premature Sebaceous Hyperplasia En Plaque with Nevus Sebaceous of the Same Distribution / 대한피부과학회지

Sebaceous hyperplasia is a common and benign disorder of the sebaceous gland. It commonly develops in middle aged to elderly persons, but the premature type can appear at puberty. Sebaceous hyperplasia usually presents as yellowish, scattered umbilicated papules on the forehead, nose, and cheeks. The term "sebaceous hyperplasia en plaque" means that numerous sebaceous hyperplasia papules are present in a grouped, plaque-like pattern. No reports of development of sebaceous hyperplasia with nevus sebaceus on the same distribution are available. Herein, we report a case of premature sebaceous hyperplasia en plaque with nevus sebaceus of the same distribution.