ABSTRACT
A case of microvenular hemangioma in a 38-year-old female is described. The patient presented with a slowly growing, solitary reddish nodule on Lt. posterior thigh, which measured 1x1 cm. Histologically, the tumor was an infiltrative growth throughout the dermis. It consisted of thin-walled, small sized, irregularly branched vessels. The vascular lumina were narrow. The flattened endothelial cells had oval to spindle-shaped nuclei and scant cytoplasm that were immunohistochemically positive for factor VIII-related antigen and smooth muscle actin. The tumor cells lacked cellular atypia, pleomorphism, and mitotic figures. We diagnosed this case as microvenular hemangioma.
Subject(s)
Adult , Female , Humans , Actins , Cytoplasm , Dermis , Endothelial Cells , Hemangioma , Muscle, Smooth , Thigh , von Willebrand FactorABSTRACT
Congenital branchial anomalies are developmental defects resulting from incomplete obliteration of branchial clefts, arches and pouches, and usually found as cysts, fistulas and sinuses. The sinus or fistula is usually noted during infancy and young childhood due to recurrent infection. We have experienced a case of branchial cleft fistula in a 12-year-old male. It was a skin colored, nontender nodule which had mucus secreting from a small opening pore. We performed complete surgical removal and histopathologically the lumen was lined by pseudostratified columnar cells and the stroma was composed of aggregates of lymphocytes with many germinal centers. So we finally diagnosed it as branchial cleft fistula of second type branchial anomaly.
Subject(s)
Child , Humans , Male , Branchial Region , Fistula , Germinal Center , Lymphocytes , Mucus , SkinABSTRACT
We report a case of primary cutaneous adenoid cystic carcinoma in a 39-year-old male patient. It was a slightly erythematous hard nodule on left chin and composed of cribriform and tubular masses of basaloid cells. Lumina formed by neoplastic cells contained mucin and hyalin, and similar constituents were located between neoplastic cell masses and adjacent dermis. Immunohistochemically, the neoplastic cells stained only focally with S-100 protein and negative with carcinoembryonic antigen(CEA). Therapy should employ wide surgical excision that extends well beyond the clinical confines of the neoplasm.
Subject(s)
Adult , Humans , Male , Adenoids , Carcinoma, Adenoid Cystic , Chin , Dermis , Hyalin , Mucins , S100 ProteinsABSTRACT
Aneurysmal fibrous histiocytoma(AFH) is a histologic variant of dermatofibroma. The importance of the recognition of AFH as a variant of dermatofibroma lies in the differential diagnosis because the histologic appearance of AFH is very similar to dermatofibrosarcoma protuberans and other vascular malignancies, such as Kaposi's sarcoma and angiosarcoma. A 32-year-old man was seen for a nodular mass on the right popliteal fossa of 4 years' duration. The excisional biopsy specimen showed a relatively well circumscribed tumor mass in the dermis. In addition to compact storiform proliferation of spindle cells, there were multiple, irregular, blood-filled, aneurysmal tissue spaces that were devoid of lining of endothelial cells. Also, deposition of hemosiderin was prominent, particularly in the periphery of the aneurysmal spaces. Immunohistochemical stain for CD34 were negative to most tumor cells. After excisional therapy, there was no evidence of recurrence during the period of ten months' follow-up.