ABSTRACT
No abstract available.
Subject(s)
Humans , Chickenpox , Dermatitis, Atopic , Herpesvirus 3, Human , Kaposi Varicelliform EruptionABSTRACT
No abstract available.
ABSTRACT
BACKGROUND: It has been reported that nail psoriasis is common in psoriatic arthritis (PsA) patients, however, studies on the prevalence of PsA with nail psoriasis and the relationship between the severity of the diseases has not previously been reported in Korea. OBJECTIVE: The aim of this study was to investigate nail psoriasis and its relation to psoriasis and PsA. METHODS: After researching past medical records, 48 patients with nail psoriasis and 247 patients without nail psoriasis were enrolled in this study. Nail psoriasis was classified according to the morphologic types of nails and severity was evaluated using the modified nail psoriasis severity score index (mNAPSI). We assessed the severity of psoriasis and PsA by psoriasis area and severity index (PASI), and swollen and tender joint counts (STJC), respectively. Finally, we analyzed the relationship between mNAPSI, PASI, and STJC. RESULTS: Nail involvement was observed in 48 (16.3%) of 295 patients. Prevalence of PsA was higher in nail psoriasis (31.3%) than in uncomplicated psoriasis (9.3%, p<0.001). mNAPSI showed a positive correlation with STJC (p=0.002, Pearson correlation=0.427), but not with PASI (p=0.094, Pearson correlation=0.202). CONCLUSION: The results show that PsA is more common and severe in psoriatic patients with nail involvement than in uncomplicated psoriasis. Clinicians should be alert to nail involvement in psoriatic patients, as it could be related to the disease course and prognosis of PsA.
Subject(s)
Humans , Arthritis, Psoriatic , Joints , Korea , Medical Records , Prevalence , Prognosis , PsoriasisABSTRACT
The Nocardia species are aerobic Gram-positive filamentous bacteria found worldwide in soil and decaying organic plant matter. Primary cutaneous nocardiosis is a rare entity and most commonly caused by Nocardia brasiliensis (N. brasiliensis). However, it can rarely be caused by N. farcinica, which is recognized as a human pathogen. Here we report a case of a 54-year-old female patient who presented with erythematous nodules on her abdomen for 1 week. She had been treated with methotrexate and prednisolone due to systemic lupus erythematosus and rheumatoid arthritis. By bacterial culture and 16S ribosomal RNA gene sequencing, the patient was diagnosed with a primary cutaneous nocardiosis caused by N. farcinica, which has not previously been reported in the Korean dermatological literature.
Subject(s)
Female , Humans , Middle Aged , Abdomen , Arthritis, Rheumatoid , Bacteria , Lupus Erythematosus, Systemic , Methotrexate , Nocardia Infections , Nocardia , Plants , Prednisolone , RNA, Ribosomal, 16S , SoilABSTRACT
BACKGROUND: Cyclosporine, which is one of the effective systemic treatments for psoriasis, has a rapid therapeutic effect. However, despite the efficacy of cyclosporine, the recurrence of psoriasis may still occur if treatment with this drug is discontinued. Several studies on the efficacy and safety of cyclosporine for psoriasis have already been conducted. However, studies on the factors causing psoriasis recurrence after cyclosporine treatment are rare. OBJECTIVE: The aim of this study was to identify the factors that cause recurrence of psoriasis in patients treated with cyclosporine. METHODS: We performed a retrospective study of the medical records obtained between January 2007 and March 2014 of 174 patients diagnosed with psoriasis and followed up for at least 6 months after treatment. We analyzed the differences in the demographic characteristics, body surface area, psoriasis area and severity index (PASI) score, psoriasis type, accompanying psoriatic nail, involvement of exposed areas, and several treatment-related factors (starting dose, last dose, maximal dose, cumulative dose, mean daily dose, and treatment duration) between the group that experienced a recurrence and the group that did not. Additionally, we analyzed the effects of these factors on the recurrence and the time to recurrence. RESULTS: Of the 174 patients, 57 (32.8%) reported a recurrence of the disease. There were statistically significant differences between the two groups in terms of their PASI score (p=0.031) and mean daily dose (p=0.014). In the multiple logistic regression analysis, the PASI score (p=0.017, odds ratio=1.057) and treatment duration (p=0.035, odds ratio=0.984) showed a significant relation with relapse. CONCLUSION: This study suggests that long-term treatment with cyclosporine is necessary for high-severity psoriasis in patients to prevent recurrence. However, as this study is retrospective, further prospective and large-scale studies are necessary to confirm this fact.
Subject(s)
Humans , Body Surface Area , Cyclosporine , Logistic Models , Medical Records , Psoriasis , Recurrence , Retrospective StudiesABSTRACT
BACKGROUND: Cyclosporine, which is one of the effective systemic treatments for psoriasis, has a rapid therapeutic effect. However, despite the efficacy of cyclosporine, the recurrence of psoriasis may still occur if treatment with this drug is discontinued. Several studies on the efficacy and safety of cyclosporine for psoriasis have already been conducted. However, studies on the factors causing psoriasis recurrence after cyclosporine treatment are rare. OBJECTIVE: The aim of this study was to identify the factors that cause recurrence of psoriasis in patients treated with cyclosporine. METHODS: We performed a retrospective study of the medical records obtained between January 2007 and March 2014 of 174 patients diagnosed with psoriasis and followed up for at least 6 months after treatment. We analyzed the differences in the demographic characteristics, body surface area, psoriasis area and severity index (PASI) score, psoriasis type, accompanying psoriatic nail, involvement of exposed areas, and several treatment-related factors (starting dose, last dose, maximal dose, cumulative dose, mean daily dose, and treatment duration) between the group that experienced a recurrence and the group that did not. Additionally, we analyzed the effects of these factors on the recurrence and the time to recurrence. RESULTS: Of the 174 patients, 57 (32.8%) reported a recurrence of the disease. There were statistically significant differences between the two groups in terms of their PASI score (p=0.031) and mean daily dose (p=0.014). In the multiple logistic regression analysis, the PASI score (p=0.017, odds ratio=1.057) and treatment duration (p=0.035, odds ratio=0.984) showed a significant relation with relapse. CONCLUSION: This study suggests that long-term treatment with cyclosporine is necessary for high-severity psoriasis in patients to prevent recurrence. However, as this study is retrospective, further prospective and large-scale studies are necessary to confirm this fact.
Subject(s)
Humans , Body Surface Area , Cyclosporine , Logistic Models , Medical Records , Psoriasis , Recurrence , Retrospective StudiesABSTRACT
BACKGROUND: Autoimmune blistering skin diseases such as pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid and epidermolysis bullosa acquisita substantially affect patients' daily life and psychosocial well-being. OBJECTIVE: The aim of this study was to evaluate the quality of life (QOL) in patients with autoimmune blistering diseases and to identify the factors that can influence their QOL by comparing them to healthy controls. METHODS: Forty patients with autoimmune blistering skin diseases and 40 healthy controls were interviewed using the Korean version of Skindex-29. The study assessed the clinical severity of the disease. RESULTS: The total, symptom, function, and emotion scores of Skindex-29 were significantly higher in patients with autoimmune blistering skin diseases (35.28, 40.78, 30.57, and 36.67, respectively) than in the healthy controls (6.90, 9.38, 5.47, and 6.60, respectively) (p<0.001). Higher disease severity had a negative correlation with QOL in patients with blistering skin diseases, and QOL was lower when patients had low levels of satisfaction with treatment. CONCLUSION: The results show that autoimmune blistering skin diseases can affect patients' QOL. In addition, disease severity and low satisfaction with treatment are important factors that reduce QOL. Development of new treatments should improve treatment efficacy and the QOL of patients with autoimmune blistering diseases.
Subject(s)
Humans , Blister , Epidermolysis Bullosa Acquisita , Pemphigoid, Bullous , Pemphigus , Quality of Life , Skin Diseases , Skin Diseases, Vesiculobullous , Treatment OutcomeABSTRACT
No abstract available.
ABSTRACT
As anti-tumor necrosis factor alpha (anti-TNFalpha) agents are progressively being used in various medical conditions, dermatological adverse events have been encountered more frequently. To understand such dermatological conditions that have been documented while undergoing anti-TNF therapy, we reviewed relevant literature, including case reports and case series. Reported dermatological conditions included infusion and injection site reaction, cutaneous infection, psoriasiform eruption, dermatitis, allergic rash, lupus-like lesion, vasculitis, lichenoid reaction, granulomatous reaction, hair loss, cutaneous infection, and cutaneous neoplasm. These events had varying strengths of causal association and severity therefore, drug discontinuation may or may not be required.
Subject(s)
Dermatitis , Exanthema , Hair , Necrosis , VasculitisABSTRACT
Vestibular papillomatosis is an uncommon benign condition that can occur on labia minora and is considered as a normal anatomical variant of the vulva, as the female equivalent of pearly penile papules in men. Because vestibular papillomatosis resemble condyloma, it can be misdiagnosed as condyloma acuminatum and can lead to unnecessary treatment. We herein report a case of a 27-year-old women with multiple skin-colored soft papules on labia minora. The lesion was distributed symmetrically on the inner of labia minora and showed a separate base of individual projection. To the best of our knowledge, this is a unique case reported in the Korean dermatological literature.
Subject(s)
Female , Humans , Male , Papilloma , VulvaABSTRACT
Fasciitis can occur very rarely with sclerotic-type chronic cutaneous graft-versus-host disease (GVHD). A 54-year-old woman presented with painful skin tightness on upper and lower limb with limited range of movement. She was diagnosed with chronic myelocytic leukemia 5 years ago and underwent allogeneic bone marrow transplantation. Histopathologically, the interlobular septum of subcutis and fascia were remarkably thickened with fibrosis and moderate inflammatory infiltrates accompanying the dilated lymphatic channels with considerable leakage of lymph fluids. Herein, we report a case of extensive fasciitis as a manifestation of chronic GVHD associated with poor prognosis.