Lipoma of the transverse colon with intussusception: A case report / 대한내과학회지

Colonic lipomas represent the most frequent mesenchymal benign tumors of the large intestine after hyperplastic polyps and adenomatous polyps, but the pathogenesis is unclear. These tumors are composed of mature fatty tissue and usually arise in the submucosa. They are usually solitary and small, and may be sessile or pedunculated. Most patients are asymptomatic and their tumors are often detected incidentally, but tumors larger than 2 cm tend to produce change in bowel habit, abdominal pain, rectorrhagia and complications such a luminal obstruction or intestinal intussusception. Diagnosis may be aided by colonoscopy with biopsy, barium enema and computed tomography. Colonic lipomas occur most often in the right colon, particularly in the ileocecal valve. Some cases of such lipoma of transverse colon have been reported in Europe and the United States, but rare in Korea. We report a case of lipoma of the transverse colon that was originated in subserosa and presented as a intussusception in a 63-year-old woman with brief review of literatures.

Fluoxetine-induced Acute Toxic Hepatitis / 대한간학회지

Fluoxetine (Prozac ) is a antidepressant that inhibits the reuptake of serotonin in central nervous system, and has lesser adverse effects than the tricyclic antidepressants. The adverse effects of this drug are various, and the most common side effects are headache and nausea. The hepatic injury caused by fluoxetine is reported but very rare and not well known. Literature review has shown only 3 cases of hepatotoxicity from fluoxetine. We regard our case as the first of the hepatotoxicity from fluoxetine in Korea. The patient that we experienced showed normal aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values before fluoxetine administration. 15 days after she took fluoxetine, AST and ALT values were increased and gradually increased as she took fluoxetine daily. We studied about viral hepatitis, metabolic liver disease, and autoimmune liver disease, but the cause of hepatic injury was not established. After the patient stopped to take fluoxetine, AST and ALT values decreased. A liver biopsy showed a moderate infiltration within the portal tracts with lymphocytes and ballooning degeneration of hepatocytes. We concluded fluoxetine-induced acute toxic hepatitis had occured. We must keep in mind that fluoxetine may cause hepatitis without cholestasis and suggest taking liver function tests regularly.