ABSTRACT
Hepatitis C virus (HCV) infection is present in a high proportion of patients with kidney transplantation. Compared with uninfected kidney transplant recipients, HCV infected kidney recipient have higher prevalence of liver disease and worse allograft survival after transplantation. Interferon monotherapy before transplantation is standard therapy for HCV-infected kidney transplant candidates. If HCV infection is discovered after transplantation, interferon monotherapy is considered due to the limited critical situation. However, in this patient, who was a kidney recipient, HCV infection was treated after kidney transplantation with peginterferon-α and rivabirin. As a result, the patient achieved sustained virologic response.
Subject(s)
Humans , Allografts , Hepacivirus , Hepatitis C, Chronic , Hepatitis, Chronic , Interferons , Kidney Transplantation , Kidney , Liver Diseases , Prevalence , Ribavirin , Transplant RecipientsABSTRACT
BACKGROUND/AIMS: Narrow band imaging (NBI) endoscopy can be used for gross differentiation between the types of colonic polyps. This study was conducted as a retrospective study for estimation of the interobserver and intra-observer agreement of the pit pattern of the mucosal surface and the accuracy of histology prediction. METHODS: A total of 159 patients underwent complete colonoscopy and 219 polyps examined by NBI endoscopy without magnification were assessed. Interobserver and intra-observer agreement were calculated by investigators in each group for determination of the surface pattern and prediction of histology based on the modified Kudo's classification using intraclass correlation coefficient. RESULTS: Interobserver agreement for the surface pit pattern and prediction of polyp type was 0.84 and 0.73 in experienced endoscopists, and 0.86 and 0.62 in trainees, respectively. Intra-observer agreement for the surface pit patterns and prediction of polyp type was 0.81, 0.83, 0.85, 0.83, 0.56, 0.84, 0.51, 0.83, and 0.71; and 0.71, 0.70, 0.82, 0.54, 0.72, 0.37, 0.51, 0.34, and 0.30, respectively. The diagnostic accuracy for prediction of polyp type was 69.4% for experienced endoscopists and 72.9% for trainees. CONCLUSIONS: NBI endoscopy without magnification showed fairly good inter and intra-observer agreement for the pit pattern of the mucosal surface and the accuracy of histology prediction; however, it had some limitation for differentiation of colon polyp histologic type. Training and experience with NBI is needed for improvement of accuracy.
Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Adenoma/diagnosis , Carcinoma/diagnosis , Colonic Neoplasms/diagnosis , Colonic Polyps/pathology , Colonoscopy , Diagnosis, Differential , Narrow Band Imaging , Retrospective StudiesABSTRACT
OBJECTIVES: The aim of this retrospective study was whether serum Tg predicts malignancy in follicular or Hurthle-cell neoplasms on fine needle aspiration. METHODS: A chart review of 111 patients (90 females, 21 males; mean age 46.8 +/- 11.9 years) with follicular or Hurthle-cell neoplasms on fine needle aspiration, who were surgically treated between Sep. 2001 and Sep. 2011, was performed. Predictive factors for malignancy were identified by the chi-squared test and multivariate logistic regression. RESULTS: There were no differences between 41 malignant and 70 benign lesions in serum Tg or any of the normalized indexes. Receiver-operator characteristic analysis revealed no cut-off value. Lesions with serum Tg levels greater than 500 g/L had no significant difference. And also there were no independent predictors of malignancy by multivariate logistic regression. CONCLUSIONS: In this study, the author found that serum Tg has poor accuracy for predicting malignancy in follicular or Hurthle cell neoplasms on fine needle aspiration.
Subject(s)
Female , Humans , Male , Biopsy, Fine-Needle , Diagnosis , Logistic Models , Retrospective Studies , Thyroglobulin , Thyroid Gland , Thyroid NeoplasmsABSTRACT
Erythema nodosum is the most common form of septal panniculitis and the most frequent skin manifestation associated with inflammatory bowel disease, affecting up to 15% of Crohn's disease patients. Since the development of erythema nodosum is closely related with a variety of disorders and condition, it can serve as an important early sign of systemic disease. Here, we present the occurrence of erythema nodosum as an early sign of Cronh's disease in a 16-year-old woman.
Subject(s)
Adolescent , Female , Humans , Anti-Inflammatory Agents/therapeutic use , Azathioprine/therapeutic use , Colonoscopy , Crohn Disease/complications , Erythema Nodosum/complications , Mesalamine/therapeutic use , Prednisolone/therapeutic use , Skin/pathologyABSTRACT
Human anisakiasis may occur after ingestion of raw marine fish infected with the nematode larvae of Anisakidae. Clinical symptoms such as cramping abdominal pain, nausea, vomiting, diarrhea and epigastric fullness, usually develop within 12 hours after having eaten infected raw sea fish. Anisakiasis is most commonly found in the stomach, and is rarely identified in the small intestine, large intestine, and esophagus. We report two cases of of anisakiasis, one with concurrent invasion of the stomach and esophagus, and the other case with esophageal anisakiasis. Both were treated by endoscopic extraction of the larvae.