ABSTRACT
Juvenile rheumatoid arthritis (JRA) can develop the extra-articular manifestations, which are growth retardation, osteopenia, chronic uveitis, and rarely pleuropulmonary involvement. Approximately 30% of patients with JRA show abnormal pulmonary function test without pulmonary symptoms, in which the frequent abnormality is in carbon monoxide diffusing capacity, but clinically evident pulmonary parenchymal disease in JRA is extremely uncommon. We describe a 23-years-old female with JRA who presented with dyspnea due to interstitial lung disease and pulmonary hypertension. She had suffered from polyarthralgia and dyspnea since 8 years old.
Subject(s)
Child , Female , Humans , Arthralgia , Arthritis, Juvenile , Bone Diseases, Metabolic , Carbon Monoxide , Dyspnea , Hypertension, Pulmonary , Lung Diseases, Interstitial , Respiratory Function Tests , UveitisABSTRACT
Experinece in the management of 74 patients with delayed traumatic intracranial hemorrhage(DTICH) of 474 head injury from January 1996 to December 1996 is poresented with emphasis on the incidence, occurring time, risk factors and outcome. The incidence of DTICH was 15.6% of all hospitalized head-injury patients. After an injury, every patient had an immediate computerized tomography(CT) scan to diagnose intracranial pathology and then CT follow-up was carried out according to intial CT finding and reurological deficit. The lesion was almost occurred in patients with initial abnormal CT finding(85.1%). 82.4% of DTICH were noted within 72 hours after injury. The delayed epidural hematoma and intracerebral hemorrhage were almost noted in first 72 hours(>90%), but the delayed subdural hemorrhage was found after a time interval varying from 6 hours to 10 days. So we strongly recommend CT follow-up in 4-8hour, 24-72hour, and then 7th day after head injury, especially in patients with initial abnormal CT findings. The risk factor of the delayed lesion was not hypotension, hypoxia, and consciousness level, but age of patients and the initial CT finding. The development of DTICH was not heralded by neurological deterioration. The prognosis of DTICH was not worse than non-DTICH. The patient with delayed subdural hemorrhage was better than the patient with non-delayed lesion(including hemorrhage and normal CT finding).
Subject(s)
Humans , Hypoxia , Cerebral Hemorrhage , Consciousness , Craniocerebral Trauma , Follow-Up Studies , Head , Hematoma , Hematoma, Subdural , Hemorrhage , Hypotension , Incidence , Intracranial Hemorrhages , Pathology , Prognosis , Risk FactorsABSTRACT
Aconitum species have been used in western and eastern medicine for centuries. In present, chinese medicine uses the drug to treat weak constitution, poor metabolism, dysuria, cardiac weakness, gout rheumatism in the limbs, neuralgia. Poisoning may occur from intentional or accidental ingestion, and the concentration of the toxic alkaloids - aonitine, mesaconitine, and hypoconitine - varies depending on species, place of origin, time of harvest, and processing procedure. In addition to cardiac arrhythmias, and hypotension, the alkaloids cause GI upset & neurological symptoms, especially numbness of the mouth and parethesia in the extrimities. The alkaloid causes a prolonged sodium current in cardiac muscle with slowed repolarization. The aconitine acts as a agonist of Na-channel receptor. Vaughan-Williams' classification I antiarrhythmic agents which belong to might be the first choice for the therapy of aconitine induced arrhythmias. The modification of the sodium system by aconitine seems to be responsible for the prolongation of the action potential and the appearance of extrasystoles and fibrillation. We experienced a 67-year-old male patient who suffered chest discomfort and palpitation with ventricular tachycardia through to be caused by aconitine. After treatment for 3days he recovered well and discharged. We report this case with literature review.