Two different cases of episodic angioedema with eosinophilia / 대한내과학회지

Episodic angioedema with eosinophilia (Gleich's syndrome) is characterized by recurrent angioedema, fever, weight gain and peripneral eosinophilia. The symptoms and clinical course differ markedly from the idiopathic hypereosinophilic syndrome, including an absence of end organ involvement and a better prognosis. A transient variant, mainly reported in Japan, which is limited to a single attack, is usually less severe than the episodic type. Here we describe two young patients, one of those is the episodic type and the other is the transient type. We suggest that episodic angioedema with eosinophilia is not rare, and should be widely recognized as a new clinical entity for accurate and prompt diagnosis. Awareness and distinction from the hypereosinophilic syndrome is important because of the favorable prognosis and rapid response to corticosteroid therapy.

CT findings of craniofacial fibrous dysplasia

Fibrous dysplasia is a benign bony disorder that contains trabeculae of poorly calcified primitive bone formed by osseous metaplasia. It is also characterized by replacement of normal spongiosa by abnormal fibrous tissues. We retrospectively analyzed the computed tomographic (CT) findings of 29 cases with clinically and radiologically diagnosed craniofacial fibrous dysplasia. In 2 cases, only cranial bones were involved and in 7 cases only facial bones were involved. Involvements of both cranial and facial bones were noted in the remained 20 cases. The commonly involved bones in the decreasing order of frequency were as follows: frontal, sphenoidal, ethmoidal and temporal bones in cranium and maxilla, zygoma, lacrimal bones and mandible in facial bones. Even though plain films are enough to diagnose the fibrous dysplasia, we think that CT is useful in more accurate diagnosis by demonstrating amorphous "ground-glass" appearance in the lesion and defining the exact extent of craniofacial fibrous dysplasia.