ABSTRACT
Objectives: It is known that the neutrophil/lymphocyte ratio [NLR] is associated with adverse outcomes in ischemic stroke patients. We aimed to reveal the association of NLR and thiol/disulfide homeostasis [TDH] with ischemic stroke patients
Methods: This study was conducted prospectively at tertiary hospital in emergency department between March 18, 2017 and November 30, 2017. It included 143 patients who were diagnosed with stroke, exhibited no hemorrhage on the Computed Tomography [CT] of the head were included in the study. Complete blood count, biochemical, TDH parameters and Ischemia Modified Albumin [IMA] were studied
Results: Neutrophil count and NLR were significantly higher in the patient group [p<0.001, p=0.001, respectively]. The mean Native Thiol [NT] value of the patient group was 359.9 +/- 84.59 Mumol/L. The mean Total Thiol [TT] value in the patient group was 399.38 +/- 86.06 Mumol/L. The NT and TT values in the patient group were significantly lower [NT/TT: p = 0.002/p = 0.007], whereas NLR and IMA were significantly higher in the patient group [p = 0.001/p < 0.001]
Conclusions: Physicians should focus on patients with increased NLR, as these patients appear to represent a population at risk for increased morbidity. We have quantitatively demonstrated in tissue oxidative stress level with TDH parameters. Investigation of these new parameters should be continued for the determination of prognostic significance
ABSTRACT
This study aimed to investigate thiol-disulfide balance in patients with renal colic who were frequently referred to emergency services and also to discuss its potential clinical use. Blood samples were obtained from 32 patients diagnosed with renal colic before treatment in the emergency department. Then, the serum thiol-disulfide levels were measured using a novel method. The patients also underwent a complete blood count test and renal ultrasonography. The thiol-disulfide values were compared statistically between the patient [those with renal colic] and control groups [healthy volunteers]. The mean native thiol level was significantly less in the patient group than in the control group. In addition, the disulfide/ native thiol and disulfide/total thiol ratios were significantly higher in the patient group than in the control group [P < 0.05]. This study found a significant difference in the thiol-disulfide balance of patients with renal colic compared with healthy volunteers. The mean native thiol and total thiol levels decreased in the patient group. It is believed that these markers may be indicative of inflammation in patients with renal colic.