ABSTRACT
Unilateral keratosis follicularis is considered a localized variant of Darier's disease and should be included in the differential diagnosis of diseases with zosteriform keratotic eruptions. It is characterized by the unilateral linear lesions in multiple locations, increased irritation by sweating, lack of solar aggravation, and negative family history. Histopathologic findings reveal acantholytic dyskeratosis similar to a generalized Darier's disease. We report a case of unilateral keratosis follicularis in a 68-year-old man, who presented with unilateral flesh-colored keratotic papules on the left axilla and inguinal area. He was effectively treated with oral 13-cis-retinoid acid (isotretinoin).
Subject(s)
Aged , Humans , Axilla , Darier Disease , Diagnosis, Differential , Keratosis , Sweat , SweatingABSTRACT
BACKGROUND: Sunscreens have been used widely to prevent the photosensitive skin diseases, skin cancer, and skin aging. However, no sunscreen blocks all kinds of effects caused by ultraviolet light(UVL), and the effect of sunscreens on the impairment of immune function by UVL irradiation is controversial. OBJECTIVE: We try to evaluate the efficiency of sunscreens for blocking the depletion of LC induced by UVB irradiation. METHOD: The ATPase positive LCs were observed in the skin of hairless mice(Hr+/Kud) irradiated by UVB with or without topical application of sunscreens. Two commercially available sunscreens with respective SPF 8 and SPF 30 were applied to the dorsal trunk skin. The mice were irradiated with different increasing doses of UVB at a single time. RESULTS: The ATPase positive LCs in the irradiated dorsal and ear skin were significantly de-creased in densities according to the dosage, and apparently revealed a loss of their dendrites, granulation, and clumping from a UVB dose of more than 60mJ/Cm2. With both sun-screen treatment on the dorsal trunk before irradiation, the densities of LCs on the dorsal skin were significantly higher compared to the un-treated groups at all ranges of UVB doses in spite of a dose dependent decrease in their density. However there was no significant difference on their preventive effect between both sunscreens(SPF 8 and SPF 30) except at high UVB dos-es of more than 240mJ/Cm². CONCLUSION: The LC depletion induced by UVB can be partially protected through the topical application of a sunscreen at a UVB dose dependent fashion. However SPF(sun protective factor) dose not appear to be a good indicator for evaluating sunscreens immunologically.
Subject(s)
Animals , Mice , Adenosine Triphosphatases , Dendrites , Ear , Langerhans Cells , Methods , Mice, Hairless , Skin , Skin Aging , Skin Diseases , Skin Neoplasms , Sunscreening AgentsABSTRACT
We report a case of hyperkeratosis of the nipple and areola occuing in 33 year old woman. She did not have a history of endocriruipathy, horrnonal therapy and other ceatoses, so this case seems to be the nevoid form by Levy-Franckel classification. Interestingly, however the lesion which had developed before marriage suddenly aggr avated during pregnancy. This may be a unique feature which has not been reported elsewhere. Histapathologic findings are compatible with breviously reported eases. There was no response to topical steroid and retinoic acid treatrnent.
Subject(s)
Adult , Female , Humans , Pregnancy , Classification , Marriage , Nipples , TretinoinABSTRACT
No abstract available.
Subject(s)
Humans , Killer Cells, Natural , Lymphocytes , T-Lymphocyte Subsets , Uterine Cervical NeoplasmsABSTRACT
No abstract available.
Subject(s)
Female , Humans , Infant, Newborn , Pregnancy , Apgar Score , Fetal Heart , Heart Rate, Fetal , Hydrogen-Ion ConcentrationABSTRACT
We report a case of sebaceous carcinoma arising from nevus sebaceus of Jadassohn ocurring in a 68-year-old male, who showed a pedunculated cauliflower like tumor mass on verrucoid linear plaque in the fronto-parietal scalp. Histopathologic findings revealed mult,iple irregular tumor lobules composed mainly of foamy cytoplasmic atypical cells suggesting undifferrntiated sebaceous cells. Good result was obtained with wide local excision and primary closure without recurrence for 9 months after surgiral excision.
Subject(s)
Aged , Humans , Male , Brassica , Cytoplasm , Nevus , Nevus, Sebaceous of Jadassohn , Recurrence , ScalpABSTRACT
The leukemias are a heterogeneous group of neoplasms arising from the malignant transformation of hematopoietic cells. The cutaneous lesions associated with leukemia may be divided into the specific (leukemic infiltration) and nonspecific (leukemids). These may occur separately or in combination with each other. A 28 year old man admitted to the Department of Dermatology in December 1989, for diffuse infiltrated skin lesions of five months duration. In July 1989, he had experienced hyperpigmented diffuse infiltration on the face, which gradually spread to involve the neck and trunk. In November 1989, he felt cervical, submandibular, and inguinal lymph node enlargement. Skin biopsy specimen showed diffuse dermal and subcutaneous infiltration of atypical lymphocytes. Bone marrow biopsy and peripheral blood smear specimen showed changes of acute lymphoblastic leukemia(L). In addition, we studied infiltrated cell.; by immunoperoxidase staining with a pannel of monoclonal antibodies. The results revealed that the atypical cells expressed mainly helper/inducer T cell marker.
Subject(s)
Adult , Humans , Antibodies, Monoclonal , Biopsy , Bone Marrow , Dermatology , Leukemia , Lymph Nodes , Lymphocytes , Neck , Precursor Cell Lymphoblastic Leukemia-Lymphoma , SkinABSTRACT
A total of 39 malignant melanoma cases diagnosed at Chonnam National University Hospital for past 10 years from 1980 to April, 1990 were included for the clinicopathologic study. Among the 29 primary cutaneous melanomas, 18 cases(62.1 % ) occurred on the hands and the feet, especially on the heel. The average age of the patients was 54.3 years at the time of diagnosis and the male to female ratio was 1 to 1,4. Acral lentiginous melanoma was the most common (62.1% ) histopathologic type and the invasion level c)f 22 cases(78.4% ) was over 1.50mm by Rreslows thickness.