In vitro chemosensitivity testing on three-dimensional collagen gel cultured human superficial bladder tumor tissue with doxorubicin, mitomycin-C and cis-platinum / 대한비뇨기과학회지

In vitro testing of cell sensitivity to anticancer drugs that results in en in vivo response is important in both cancer therapy and cancer drug development. The previous studies of in vitro human genitourinary tumors have been limited to established cell lines, short term immunohistochemical and biochemical assays, and immuno-compromised animal implantation. The ability to support the heterogeneous cell population as well as in vivo growth characteristics for in vitro study has been the goal of many investigators. Hoffman has described an assay that offers three-dimensional in vivo-like growth. This three-dimensional culture system is general and grows tumors at high frequencies either directly from surgery or biopsy. They maintain important in vivo properties in vitro. including tissue architecture. According to our studies, the drug responses of cells within the tissue structure of collagen gel supported in vitro-grown tumor tissue that had been obtained from a patient who was clinically confirmed transitional cell carcinoma of the bladder can be determined. In accordance with experimental studies. many human superficial bladder tumor surgical gel specimens that were tested metabolized glucose in a measurable fashion. There was a uniformly steady decline in the control group, which demonstrated a dose responsive suppression of this ability when exposed to effective chemotherapeutic agents. when used by itself, doxorubicin was found to be the most effective drug followed by mitomycin-c. The combination of doxorubicin and mitomycin-c were the most effective drugs followed by doxorubicin and cis-platinum in combination chemotherapy. It was not found that doxorubicin base combination was more effective than doxorubicin single use. Anticancer effect was more dominant during the post-treatment second 72 hours than first 72 hours.

Urodynamics in Patients with Chronic Prostatitis / 대한비뇨기과학회지

Urodynamic studies including uroflowmetry, CO2 cystometry, electromyography, urethral pressure profilometry were performed on 15 cases of the chronic prostatitis in the Department of Urology, Kyung Hee University Hospital recently. The following results were obtained: 1. The uroflowmetry was performed in 15 cases. The average of the maximum flow rates was 16.57+/-4.68ml/ sec (M+/-SD). In only 4 cases the maximum flow rate was within normal range, but the other 11 cases revealed decreased rates than normal. 2. The CO2 cystometry was performed in 14 cases. In only one case the bladder capacity was 1,003ml, but the other findings were normal. The other 13 cases revealed normal findings. In 12 cases the external anal sphincter EMG was performed with cystometry simultaneously, there was no detrusor-sphincter dyssynergia. 3. The urethral pressure profilometry was performed in 14 cases. The average of the functional profile length was 3.06+/-0.78cm (M+/-SD). The average of the maximum urethral pressure was 85.36+/-27.99cmH

Experiences with Cutaneous Transureteroureterostomy / 대한비뇨기과학회지

During the last two years, three patients have undergone transureteroureterostomy and cutaneous ureterostomy at the Kyung Hee University Medical Center. Two patients had marked azotemia and bilateral hydronephrosis due to neuromuscular vesical dysfunction. The other patient had advanced bladder tumor with hydronephrosis of one kidney and nonvisualization of the other kidney. Their follow-up results are satisfactory and wide application of this simple procedure is discussed.

Observation of Prostatic Secretion Cultures In Patients with Chronic Prostatitis / 대한비뇨기과학회지

An observation of prostatic secretion culture was performed on 145 cases of the chronic prostatitis in the Department of Urology, Kyung Hee University Hospital from March 1980 to February 1981. The following results were obtained: 1. Of 145 cases who performed prostatic secretion culture, 114 cases (78.6%) revealed positive culture and the remained 31 cases (21.4%) revealed negative culture. 2. Of 114 cases who revealed positive culture, 112 cases (98.4%) were Gram positive organisms. The details are as follows: Staphylococcus epidermidis, the most common organism, 74 cases (61.2%); Staphylococcus aureus, 25 cases (20.7%); Streptococcus fecalis, 8 cases (6.6%); Alpha streptococcus, 7 cases (5.8%): Diphtheroid, 4 cases (3.3%); Bacillus species, 1 case. 3. Of 114 cases, Gram negative organism, Klebsiella pneumoniae, was found in only 1 case. And the other 1 case was Candida species. 4. The culture of prostatic secretion is of great value and important procedure in the treatment and differential diagnosis of chronic non-bacterial prostatitis and bacterial prostatitis.

A Case of Bilateral Ureterocele Combined with Bladder Stone and Papillary, Cystic, Glandular Metaplasia / 대한비뇨기과학회지

Ureterocele, cystic dilatation of the lower end of the ureter, is not a common urogenital disease and occuring more frequently in female than in male. One case of bilateral ureterocele, combined with bladder stone and papillary, cystic, glandular metaplasia, was presented with a brief review of the literature.

Sinus Histiocytosis with Massive Lymphadenopathy : Report of A Case with Perineal Involvement / 대한비뇨기과학회지

The term "sinus histiocytosis with massive lyrnphadenopathy," introduced in 1969 by Rosai and Dorfman, refers to a newly recognized disease entity characterized by painless cervical lymphadenopathy, fever, leukocytosis, increased erythrocyte sedimentation rate, and hypergammaglobulinemia. The typical course is one of insidious onset, protracted duration of the active disease state, and eventual spontaneous remission, occasionally with subsequent recurrences. Lymph nodes other than those in the cervical area may be involved, and extranodal involvement can occur (such as in the orbit, skin, or respiratory tract) Clinically, this entity may closely simulate malignant lymphoma or nonneoplastic conditions with lymphadenopathy. We present a case in which this disease process involved the perineum.