ABSTRACT
Metastatic skin cancers are a relatively uncommon malignant tumor. Visceral tumors such as breast, lung, and colon cancers are commonly found to be the primary origin. Cutaneous metastasis with esophageal cancer is exceedingly rare, accounting for less than one percent of all skin metastasis. Here, we report a case of cutaneous metastatic squamous cell carcinoma that originated from esophageal carcinoma. The patient was a 48-year-old male who complained of a 2-cm-sized non-tender, skin-colored nodule on his left lower back. Positron emission tomography-computed tomography (PET-CT) showed focal fluorodeoxyglucose (FDG) uptake in the lesion. In the histopathological examination, the tumor cells stained positive for epithelial membrane antigen (EMA) and cytokeratin 5/6 (CK5/6), which was consistent with squamous cell carcinoma. This case suggests that patients who have been treated for primary esophageal carcinoma should undergo a skin biopsy to rule out metastatic skin cancer if the tumor appears to be suspicious.
ABSTRACT
Leprosy is a chronic infectious and granulomatous disease caused by Mycobacterium leprae. It is treated with a multidrug therapy (MDT), which is consisted of dapsone, rifampicin, and clofazimine. However, there were relapsed leprosy associated with various predisposing factors; persisting organism, multiple involved skin lesions and nerves, HIV infection, monotherapy, inadequate and irregular therapy. Early or late relapses were observed in leprosy. Early onset relapses may occur due to insufficient treatment, and late relapses are probably with persistent bacilli and drug resistant organisms. Herein, we report on an interesting case of a 78-year-old man presented with relapsed leprosy associated with ulcerative skin lesions. The patient was diagnosed with lepromatous leprosy about 40 years ago, and he was treated with dapsone monotherapy and MDT. Our case is thought to have occurred due to persistent bacilli related to irregular therapy.
ABSTRACT
BACKGROUND@#Inpatient dermatological consultations are getting more important and, therefore, several studies ofdermatologic consultation from various inpatient departments have recently been reported. However, data regardingthe analyses of these consultations for infectious diseases inpatients are limited.@*OBJECTIVE@#The purpose of this study was to analyze and quantify the patterns of dermatologic consultations referred by the Division of Infectious Diseases.@*METHODS@#We retrospectively reviewed 149 consultation reports for inpatients referred by the Division of Infectious Diseases from January 2014 to May 2019. We analyzed the medical records and noted age, sex, reasons for dermatologic consultation, diagnosis of the dermatoses, and change in diagnosis after the consultation in a single secondary referral center.@*RESULTS@#The percentage of patients who were referred by the Division of Infectious Diseases and consulted by the Department of Dermatology was 13.2%. The most frequent age group was the 7th decade of life (24.8%) and the male to female ratio was 1:1.04. The main reasons for dermatologic consultations were dermatologic disease not related to underlying infectious disease (43.0%), dermatologic disease related to underlying infectious disease (24.2%), and skin lesions related to the treatment (18.1%). The most common dermatoses were infectious disease (40.3%), followed by eczema (22.1%), and drug eruption, erythema and urticaria (19.5%). There were 10 cases in which the diagnosis of undetermined dermatoses was changed after dermatologic consultation.@*CONCLUSION@#This study revealed the distribution of skin disorders inpatients referred by the Division of Infectious Diseases for dermatologic consultation. In conclusion, dermatologists should take an active role in dermatologic consultations for more accurate examinations and treatment of infectious diseases patients.
ABSTRACT
An atypical teratoid/rhabdoid tumor (AT/RT) is a rare malignancy occurring in the first few years of life. This tumor shows rapid growth, a poor response to treatment, and poor prognosis. Cutaneous metastases presents as hamartomatous lesions mimicking skin tags. Immunohistochemical examination shows varied patterns of expression based on the sites of the body affected. Integrase interactor-1 (INI-1) gene sequencing and loss of expression of INI-1 observed with immunostaining can confirm AT/RT. In our patient, the skin lesion was identified at birth. Histopathological examination of the skin lesion could not establish an accurate diagnosis. Two months later, the patient presented with a brain tumor. Immunohistochemical examination of the brain lesion revealed complete loss of INI-1 expression in tumor cells, and the lesion was diagnosed as AT/RT. After that, we can detect the loss of INI-1 expression in the skin on the back. We report a rare case of AT/RT affecting the brain with cutaneous metastasis diagnosed with immunohistochemical staining.
Subject(s)
Humans , Brain , Brain Neoplasms , Diagnosis , Integrases , Neoplasm Metastasis , Parturition , Prognosis , SkinABSTRACT
Localized cutaneous argyria is a rare condition in which the skin changes into blue-grey spots due to the absorption of silver. The lesions need to be differentiated from other pigmentary disorders and require radiographic and histological examination for more accurate diagnosis. Scanning electron microscopy and energy dispersive x-ray spectroscopy can be a confirmatory tool in the evaluation of silver elements in biopsy tissue. This report shows the localized cutaneous argyria in earlobe of a 21-year-old woman who wears silver earrings for 10 years.
Subject(s)
Female , Humans , Young Adult , Absorption , Argyria , Biopsy , Diagnosis , Ear , Microscopy, Electron, Scanning , Nevus, Blue , Silver , Skin , Spectrometry, X-Ray EmissionABSTRACT
No abstract available.