Evaluation of the Voice Parameters Following Supracricoid Partial Laryngectomy / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: Conservation laryngeal surgery is designed to remove the cancer mass completely while preserving the physiologic functions of the larynx. Recently, the supracricoid partial laryngectomy (SCPL) has broadened the spectrum of reliable techniques available to conservation laryngeal surgeons. Much research has been devoted to the surgical technique and oncological results of SCPL, but only a few signi6cant objective reports of the phonatory results are available presently. This study was designed to analyze the phonatory results achieved after SCPL for laryngeal cancer. MATERIALS AND METHODS: Selected characteristics of the speech and voice were compared in 25 patients who had undergone SCPL and 10 normal adult laryngeal (NAL) speakers. Durational and frequency features were analyzed with the CSL and the MDVP. RESULTS: SCPL speech proved comparable to NAL speech at the average fundamental frequency. SCPL spech and voice were statistically less efficient than NAL speech in jitter, shimmer, harmonics-to-noise ratio, mean airflow rate, maximal phonation time, and subglottic pressure (p<0.01). The completion of an arytenoid cartilage resection and/or anterior cricoid cartilage removal did not statistically modify the durational and frequency features of SCPL speakers (p <0.01). CONCLUSION: The voice parameters of SCPL speakers were different from those of the NAL speakers, but patients were thought to be allowed social interaction.

Expression of Cytokeratin Subtypes in Advanced Laryngeal Carcinoma and Its Relationship to p53 and Human Papilloma Virus / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: This study investigated the expression of cytokeratin 8, 18, 19 with low molecular weight, which have been classified as a group of simple epithelium-related marker for advanced squamous cell carcinoma of the larynx. MATERIALS AND METHODS: Detection of cytokeratin expression was performed by immunohistochemical study using antikeratin monoclonal antibodies (CAM5.2, RCK108). Immunohistochemical study was used further to detect the presence of p53 mutation in larynx carcinoma, and PCR was performed to detect the infection of HPV. We then tried to draw relationship among these factors with regard to advanced larynx carcinoma. RESULTS: Cytokeratin 8, 18 (CAM5.2) was detected in 17 cases among the 19 advanced larynx carcinoma, and in 3 cases among the 15 normal larynx. Cytokeratin 19(RCK108) was detected in 18 cases among the advanced larynx carcinoma, and in 11 cases among the 15 normal larynx. HPV DNA was detected in 4 of the 19 cases of larynx carcinoma. With regard to subtypes of HPV, HPV 16 was detected in 2 cases. And p53 was detected in 6 out of the 19 cases of larynx carcinoma. There was no correlation among the cytokeratin expression, the p53 expression, and the HPV infection. CONCLUSION: This results show that cytokeratin 8, 18 (CAM5.2) expression might be a meaningful parameter in malignant change of the larynx, but the prognostic role of the cytokeratin and the role of p53 and HPV in cytokeratin expression in larynx carcinoma was not confirmed.