ABSTRACT
Paclitaxel is one of the taxoid-antineoplastic agents. These agents are used in the treatment of breast, lung and ovary cancer. Nail changes due to treatment with the taxanes (mainly docetaxel) are reported in 30~40 percent of patients. Paclitaxel is not commonly associated with dermatological reactions, although localized skin reactions and tissue necrosis following extravasation have been reported. Reports of the incidence of nail changes associated with paclitaxel is noted as the pigmentation or discoloration of the nail bed, vary from 2~20%. We report a patient with onycholysis and subungual suppuration during treatment with paclitaxel.
Subject(s)
Humans , Breast , Incidence , Lung , Nails , Necrosis , Onycholysis , Ovarian Neoplasms , Paclitaxel , Pigmentation , Skin , Suppuration , TaxoidsABSTRACT
In January 2006, Sunitinib was approved by the US Food and Drug Administration for the treatment of advanced renal cell carcinoma and gastrointestinal stromal tumor. Sunitinib inhibits the receptor tyrosine kinases that are involved with various receptors whose functions are related to tumor growth, angiogenesis and metastatic progression. The cutaneous adverse reactions of hand-foot syndrome associated with sunitinib are well known, but there have been no previous reports on these reactions in the Korean medical literature. We report here on a case of hand-foot syndrome due to this drug, and we discuss the possible mechanism of hand-foot syndrome caused by sunitinib.
Subject(s)
Carcinoma, Renal Cell , Gastrointestinal Stromal Tumors , Hand-Foot Syndrome , Indoles , Paronychia , Phosphotransferases , Pyrroles , Tyrosine , United States Food and Drug AdministrationABSTRACT
In January 2006, Sunitinib was approved by the US Food and Drug Administration for the treatment of advanced renal cell carcinoma and gastrointestinal stromal tumor. Sunitinib inhibits the receptor tyrosine kinases that are involved with various receptors whose functions are related to tumor growth, angiogenesis and metastatic progression. The cutaneous adverse reactions of hand-foot syndrome associated with sunitinib are well known, but there have been no previous reports on these reactions in the Korean medical literature. We report here on a case of hand-foot syndrome due to this drug, and we discuss the possible mechanism of hand-foot syndrome caused by sunitinib.
Subject(s)
Carcinoma, Renal Cell , Gastrointestinal Stromal Tumors , Hand-Foot Syndrome , Indoles , Paronychia , Phosphotransferases , Pyrroles , Tyrosine , United States Food and Drug AdministrationABSTRACT
BACKGROUND: Recently, the use of cellular phones has greatly increased, and allergic contact dermatitis (ACD) ascribed to the use of cellular phones has been one of the problems. OBJECTIVE: The purpose of this study was to evaluate clinical characteristics of allergic contact dermatitis due to cellular phone use. METHODS: Three male and 7 female patients who were diagnosed as ACD due to cellular phone use were evaluated. A patch test was performed on the upper back and any history of metal allergy was checked. We also evaluated the content of nickel in the cellular phones currently being sold on the market, using a dimethylglyoxime spot test. RESULTS: The results of this study are summarized as follows; There was female predominance in cellular phone dermatitis with an average onset of age 27.4 years old. A history of metal allergy was found in 40.0% of the patients. The most common site and mobile phone type were cheek (60.0%) and slider type (60.0%), respectively. In addition to erythematous patches, itching was accompanied in 60.0% of the patients. But the other patients did not report any pruritus at all. Except in three cases, patch tests were performed on the upper back. Five patients were positive to nickel and 4 patients were positive to chrome. The dimethylglyoxime test showed 21.2% positivity in 104 cellular phones of 27 different models. CONCLUSION: Cellular phone dermatitis usually occurs on both cheeks, or the dominant hand-sided cheek area. The causative metals are mostly nickle and chrome.
Subject(s)
Female , Humans , Male , Cell Phone , Cheek , Dermatitis , Dermatitis, Allergic Contact , Hypersensitivity , Korea , Metals , Nickel , Patch Tests , PruritusABSTRACT
BACKGROUND: Solar urticaria is an uncommon photodermatosis characterized by the appearance of wheals after sun exposure. Although many sporadic cases have been reported, little is known about the clinical characteristics in Korean patients. OBJECTIVE: The purpose of this study was to investigate the clinical characteristics of solar urticaria in Korean patients, with an emphasis on demographic characteristics and action spectrum. METHODS: A retrospective analysis was conducted of the records of patients phototested at Seoul National University and subsequently diagnosed with solar urticaria. RESULTS: A total 11 solar urticaria patients were used in this study. The mean age was 24 years. Nine (82%) patients were male and two patients (18%) were female. The mean age of onset was 20.8 years. The mean exposure time to wheal formation was 24 minutes and mean duration of wheal was 98 minutes. The action spectra of solar urticaria were visible light for 6 (55%) patients, ultraviolet A (UVA) for 2 (18%), both visible light and UVA for one (9%), both visible light and UVB for one, and natural sunlight for one. CONCLUSION: Visible light was the most common action spectrum in this study. Our findings illustrate the clinical and photobiological characteristics of solar urticaria in Korean patients.