A Study on the Change of Xanthine Oxidase Activities in Experimental Cerebral Infarction

To observe the activity of the xanthine oxidase in cerebral ischemia, an ischemic model was made using a transorbital occlusion of the middle cerebral artery(MCA) in cats. Xanthine oxidase activity was measured by means of high performance liquid chromatography with electrochemical detection of uric acid. The results were as follows: The infarction in the territory of the left middle cerebral artery(MCA) was identified with intracardiac perfusion of a 2% triphenyltetrazolium chloride(TTC) solution after transorbital occusion. 2) There was no significant difference between the control and ischemia groups in the total xanthine oxidase activity. 3) In the control group, 38.2% of the total xanthine oxidase was in the oxygen-dependent superoxide-producing oxidase group(Type 0). It had been increased with time in ischemia, despite the total xanthine oxidase activity remaining the same;particularly at 12 hours(p<0.05) and 24 hours(p<0.01) after occlusion of the left MCA. 4) In the healthy side, the activity of type 0 and its ratio to the total xanthine oxidase activity has not been increased. 5) In the ischemic side, the conversion of type D xanthine oxidase to the type 0 xanthine oxidase was demonstrated and its rate had been increased with the passage of time.

A Clinical Analysis of Spontaneous Cerebral & Cerebellar Hematoma

The Clinical analysis of 130 spontaneous intracebral & cerebellar hematoma confirmed by brain CT & admitted to this neurosurgical clinic past years & 5 months were made with literature review. 1) The age incidence showed increase over fourth decade and male to female ratio was 56.1:43.9. 2) 50.4% of total patients showed hypertension but 40.3% did not checked their B.P. & 9.3% had normal B.P. before cerebral hemorrhage. Among 50.4% of hypertension cases, 72% received antihypertensive treatment intermittently, 2.9% regularly and the rest 24.3% did not. 3) 69.7% of hematoma located in basal ganglia & thalamus. In nonoperated patients, the morbidity & mortality showed no marked difference in their location except pontine & cerebellar hematomas. In operated patients the morbidity & mortality was prominent in putaminal hemorrhage than in thalamus and cerebellum. Most of putaminal hematoma had semicomatose or comatose mental state and ventricular hemorrhage in 87.5%. 4) The morbidity & mortality increased in proportion to size of hematomas, grade of unconsciousness in admisson and state of intraventricular hemorrhage. 5) About time interval from ictus to operation, the patients within first 24 hours are 29 cases(51.1%) and the next 24 hours are 13 cases(26.5%). The mortality rate of two groups were 55.1% & 53.8% respectively but no death in the patients with operation performed after 48 hours. 6) The morbidity & mortality rate were as follows. In the non operated patients (90 patients), no or mild neurological deficits:22.2% moderate:21.1% severe:20% and moribund or death:36.6%. In the operated patients no or mild neurological deficits:16.3% moderate:18.4% severe:18.4% and moribund or death:46.9%. The results of total patients showed no or mild neurological deficits:20.1%, moderate:20.1%, severe:19.4% and moribund or death:40.2%.