The Effects of Dantrolene Sodium in Prevention of Malignant Hyperthermia / 대한마취과학회지

Malignant hyperthermia is defined as a potentially fatal hypermetabolic syndrome char-acteriged by hyperpyrexia, muscle rigidity, tachycardia, respiratory and metabolic acidosis. cyanosis etc. It ia susceptible in patients with musculoskeletal diaease such as strabismus, kyphosco-liosia, hernia, cleft palate, cryptorchidism, but there is no single diagnostic method to detect a susceptible patient. Fortunately s-CPK is elevated in 70% of carriers, so we checked a-CPK and a-LDH bel- ore operation in patients scheduled for correction of congenital strabismus and classified into group 1 (norirlal a-CPK group) and group 2 (elevated s-CPK group) . We administered Oantrolene sodium to group 2 before operation and compared the changes of s-CPK and s-LDH after operation. The results are as fallows, 1) s-CPK was lowered after administration of Dantrolene sodium in group 2 . (from 76.4 IU/L to 48.5IU/L) 2) s-CPK elevation after operation was much less in group 2 than group 1. (56.1+/-58.7 IU/L vs 164.7+/-127.1 IU/L) In conclusion, it would seem that Dantrelene aodium was affective in prevention of mali-gnant hyperthermia.

Bilateral Tension Pneumothorax during General Anesthesia - Case report / 대한마취과학회지

Pneumothorax was recognized as a potential hazard of mechanical ventilation shortly after the introduction of the technique of tracheal intubation in the 19th century. Because the gases used in anesthesia are delivered from cylinders and wall outlets at higher than atmoshperic pressure, the possibility of damage to the lung is ever present. Immediate, prompt and adequate management of bilateral tension Pneumothorax are essentil, otherwise the patient dies rapidly. We had a case of bilateral tension Pneumothorax in a 3 year-old boy who underwent a B-E amputation of a severely crushed hand. We report this case along with a review of the literature on Pneumothorax.