Comparison of anticardiolipin antibody and antiphospholipid antibody in women with recurrent abortions

Recurrent abortion is a critical problem in which many factors play a crucial role such as anticordiolipin antibody and antiphospholipid antibody. This study was conducted to evaluate the frequency of anticardiolipin antibody and antiphospholipid antibody in pregnancy failures in women with the history of recurrent pregnancy loss. In 154 women with the history of two or more recurrent pregnancy losses, serum anticardiolipin and serum antiphospholipid were measured using ELISA method. The positive IgG anticardiolipin and IgG antiphospholipid were detected in 12. 34% [19 patients] and 6.5% [10 patients] of patients respectively. Although 16 out of 19 patients with positive IgG anticardiolipin were negative for IgG antiphospholipid and 7 out of 10 patients with positive IgG antiphosphplipid were negative IgG anticardiolipin, but there was a significant correlation between IgG anticardiolipin and IgG antiphaspholipid [r = 0.222 p=0.000]. Our data concluded that anticardiolipin antibody is found to be more important than anti phospholipid antibody in recurrent abortion

Relationship between anti-thyroid peroxidase antibody and thyroid function test

Anti-thyroid peroxidase antibody [anti-TPO antibody] is a member of thyroid autoantibodies which are important in inducing and also diagnosing autoimmune thyroid diseases. Thyroid autoimmunity can cause several forms of thyroiditis and abnormal thyroid functions, ranging from hypothyroidism to hyperthyroidism. To evaluate the relationship between serum levels of anti-TPO antibody and thyroid function test parameters [T3, T4, and TSH] in patients with thyroid disease. In 2425 subjects suspected of having thyroid disease referred to Yazd central medical laboratory by physicians during a 2 year period, the concentrations of serum anti-TPO antibody [ELISA] and T3, T4, and TSH [RIA] were measured. 53.53% of the patients were 20 to 39 years old. 2135 patients [88.04%] were female and 290 [11.96%] were male. The levels of T3, T4, and TSH in individuals with normal and raised anti-TPO antibody titers was significantly different [P<0.0001]. A correlation between TSH and T4 levels and abnormal anti-TPO antibody was detected [P=0.002]. Our results confirm the correlation between thyroid function test and anti-TPO antibody values, indicating the clinical significance of this antibody and suggesting a through clinical examination and follow up of individuals with high anti-TPO antibody titer