ABSTRACT
Background: Proteins necessary for DNA replication and normal regulation for the cell cycle include minichromosome maintenance-2 (Mcm-2). Overexpression of this protein in several premalignant and malignant lesions has been observed. In this study, the diagnostic value of Mcm-2 expression in distinguishing histologically-proven normal oral mucosa (NOM), oral benign keratosis (OBK), oral epithelial dysplasia (OED), and oral squamous cell carcinoma (OSCC) was investigated. Materials and Methods: In this descriptive analytical study, 73 archived specimens of oral tissues, including 20 OBK, 20 OED, 20 OSCC, and 13 NOM cases were selected. The means of labeling indices (LIs) of Mcm-2 expression by immunohistochemistry in each category of lesions were calculated. The data was analyzed by one–way ANOVA, discriminant analysis, and Fisher’s exact tests. Results: The means of labeling indices (LIs) of Mcm-2 expression show statistically significant difference between the four studied groups (P<0.001). Mcm-2 had overexpression and higher positivity in OSCCs. A cut-off point of 67% was determined in order to distinguish OSCC from precancerous lesions. Conclusion: The findings indicated that Mcm-2 could be a useful marker for early detection of oral SCC and dysplasia. Also, due to the overexpression of this marker in OSCC, there exists the possibility of application of Mcm-2 for molecular target therapy in these patients.
ABSTRACT
Lichen planus is a relatively common, chronic mucocutaneous disease with the risk of malignancy. In recent years, there have been increases in the prevalence of oral lichen planus [OLP] and it looks there are some changes in the epidemiologic pattern of this lesion. Despite the existence of different studies about the changes in OLP lesion epidemiology, this study aimed to investigate epidemiologic changes of oral lichen planus in patients referred to the Oral Pathology Department of Isfahan Dental School [1988-2008]. In this descriptive study, archives of the Oral Pathology Department from 1988-2008 was reviewed. Sex, age, location and type of lesion and the referral year were recorded. Data were analyzed by one-way ANOVA with SPSS 11.5 statistical software. A total of 6509 patients had been referred to the Oral Pathology Department, with 238 [3.65%] of cases diagnosed with OLP; 154 [64.7%] of the cases were females. The mean age of OLP patient was 44.8 +/- 12.7 years. Buccal mucosa was most frequently involved [68.1%].An increase in the number of patients and decrease in mean age of the patients with OLP was noted, which might be attributed to population growth and an increase in the number of cases referring to dental practitioners, or more accurate diagnosis in recent years. Therefore, regular follow-up programs are recommended for the diagnosis and treatment of high risk groups
ABSTRACT
Lipoma is a common tumor of soft tissue. Its location on the oral mucosa is rare, representing 1% to 5% of benign oral tumors although it is the most mesenchymal tumor of the trunk and proximal portions of extremities. Lipoma of the oral cavity may occur in any region. The buccal mucosa, tongue, and floor of the mouth are among the common locations. The clinical presentation is typically as an asymptomatic yellowish mass. The overlying epithelium is intact, and superficial blood vessels are usually evident over the tumor. Other benign connective tissue lesions such as granular cell tumor, neurofibroma, traumatic fibroma and salivary gland lesions [mucocele and mixed tumor] might be included in differential diagnosis. We present two cases of oral lipoma in unusual locations: one in junction of soft and hard palate and the other in tongue. Both were rare in the literature