ABSTRACT
Background: Intracerebral Hemorrhage [ICH] is a stroke type which resulted in disability. Memantine have been supposed to have the effect on the functional status in patients with ICH
Objectives: Comparing the effect of memantine with placebo on the clinical outcome of ICH
Materials and Methods: This double-blind clinical trial was conducted in an academic hospital in northern Iran on patients with ICH allocated in memantine and placebo group through the random block method
The patients' neurological status was assessed on admission, the seventh day, upon discharg and ultimately three months after the ICH onset, according to the Nationa Institute of Health Stroke Scale [NIHSS], modified Rankin Scale [mRS] Barthel Index [BI] and Glasgow Coma Scale [GCS]
The data analysis was done by using independent t-test, Chi-square and repeated measure tests SPSS software version 21
Results: A total of 64 patients have been allocated into two equal size group! with no significant differences in terms of age or gender [p>0.05]
The meal increase in the BI and the decrease in the mRS were significantly greater in tW memantine group compared with the placebo group as measured fron admission time until three months following the ICH onset [p=0.001 anc p=0.049, respectively]
No significant differences were observed between the two groups in mortality rate [p=QA92] and the means and changes of the GCS [p=0.331] and the NfflSS score [p=0.211]
Conclusion: Early administration of memantine to ICH patients can result ii significant improvement of long-term motor function and functional independence