ABSTRACT
Bipolar 1 disorder [BID] and its treatments have shown to be associated with deep impacts on patients' subjective feelings and quality of life [QOL]. There are also some comments about impact of these feelings on course and outcome of patients with BID. This study was aimed to evaluate quality of life in patients with BID and to assess its relationship with course of disorder. Fifty patients with BID were recruited based on the Structured Clinical Interview for DSM-IV Axis I Disorders [SCID-I] from May 2008 and followed for 12 months. Quality of life and mood disorder recurrence were assessed through World Health Organization Quality of Life and SCID-I tools respectively at baseline and after 6 and 12 months. Repeated j measures analysis and logistic regression were used to analyze the independent effect of QOL and demographic factors on BID recurrence. Fifty patients [66% male; 48% never married; 48% in primary school level] with mean +/- SE age and age of BID onset 33.8 +/- 1.5 and 26.6 +/- 1.1 years were studied. They had 3.4 +/- 0.6 episodes already. Twenty eight percent suffered from recurrences during the follow-up. The QOL scores at baseline, after 6 and 12 months were 70 +/- 1.8, 69.6 +/- 1.1 and 73 +/- 1.3 respectively. There were no significant change in QOL and its sub-domains during the follow-up [P=0.37]. QOL showed no independent relationship with BID recurrences [P>0.1]. No change in the QOL during the follow-up could denote lack of effectiveness of routine interventions on this factor. Also, short-term follow-up might be concerned as the f possible reason. Of prime importance is to consider quality of life independently in treating patients with bipolar disorder
ABSTRACT
Our purpose in this research was to evaluate the correlation between skill in chess [international chess rating scale] and severity of depression and anxiety and ten cognitive errors in members of Iranian Chess Federation that have international chess rating scale as well as to study the prevalence of depression and anxiety in the sample. 96 persons that had an international chess rating scale were sampled with convenient method and took part in this cross sectional study. All samples completed the second version of Beck Depression Inventory, Beck Anxiety Inventory and Cognitive Error Test. Data were analyzed with SPSS software. There was a significant reverse correlation between chess rating scale and four cognitive errors including over generalization, magnification, jumping to conclusion and must statement. The depression severity decreased by increasing the numbers of hours of game playing in the day. Also there was a reverse significant correlation between chess skill and depression severity, but chess skill had no significant correlation with severity of anxiety. The prevalence of mild moderate depression was 16.7%. There was no case with severe depression. The prevalence of mild and moderate anxiety was 27.1% and severe anxiety was 5.2%.We conclude that this significant reverse correlation between chess rating scales and depression severity is mediated by decrease of cognitive errors and the number of the hours of game playing in the day, which is in accordance with Beck's Cognitive Theory and Behavioral Activation Theory
ABSTRACT
To systematically review studies on attitude, knowledge, and satisfaction of health personnel and general population about the program of integration of mental health in PHC in the recent 20 years. International and local databases were electronically searched. Hand searching, reviewing reference lists and personal communications were also done. 11 studies on attitude and knowledge and one study on satisfaction were selected after reviewing full texts of the documents. Most studies were on Behvarzes and general population and few studies assessed other groups. Knowledge of the studied groups were higher than average in most studies. The only satisfaction study suggested a medium, high, and low satisfaction of general population from interpersonal and care delivery, time and cost benefit, and treatment outcomes, respectively. Knowledge and attitude of the personnel and general population seems to be average or higher in most studies. This could be partly due to implementation of the integration program. However, more empirical data is needed to evaluate the issues more specifically
ABSTRACT
The methylenetetrahydrofolate reductase [MTHFR] gene polymorphism C677T is suspected to be a risk factor for psychiatric disorders, but it remains inconclusive whether the MTHFR polymorphism C677T is imputed to vulnerability to schizophrenia and bipolar disorder. We prompted impetus to appraise this polymorphism in an Iranian population. Therefore, 90 patients with bipolar disorder type I [BID], 66 patients with schizophrenia diagnosed according to DSM-IV criteria, and 94 unrelated controls with no history of psychiatric disorders were recruited for this study. Genotype distribution and allelic frequencies of C677T polymorphism were investigated. We found no robust differences between patients with BID and schizophrenia with control participants either for allele frequencies or genotype distribution of MTHFR C677T polymorphism. However, a trend toward an increased risk for T allele was observed in the BID patients [with odds ratio [OR] of 1.28[CI 95%: 0.8-1.31], p>0.05]. However, the present and some previous studies failed to elucidate possible interaction between MTHFR C677T polymorphism and vulnerability to schizophrenia and bipolar disorder; still some associations have been revealed in performed meta-analyses that warrant further studies