[Evaluation of effectivness of Nigella sativa extracts and topical honey application versus topical honey alone along with intralesional injection of Glucantime in the treatment of acute cutaneous leishmaniasis]

There are some reports regading the anti-inflammatory and antimicrobial effect of honey and Nigella sativa and their therapeutic effects in improvement of wound healing. This study was designed to evaluate the efficacy of adding honey and Nigella sativa extract compared to honey alone in patients with cutaneous leishmaniasis receiving intralesional Glucantime. In this clinical trial, 150 patients with confirmed cutaneous leishmaniasis were randomly allocated into two groups. One group was treated with topical honey twice daily along with weekly intralesional injection of Glucantime. In the second group, patients were treated with topical honey and 60% hydroalchoholic Nigella sativa extract instead of honey alone. The patients were treated until complete healing of the ulcer or for maximum of 12 weeks. At 12 weeks, complete cure was achieved in 61 [81.3%] of patients treated with topical honey and 60% hydroalchoholic Nigella sativa extract versus 48 [64%] in the second group [P=0.002]. The efficacy of adjunct honey and Nigella sativa extract along with intralesional Glucantime is more than honey alone in increasing complete cure rate and decreasing the residual scar size and the required dose of Glucantime

Effects of a nitric oxide releasing cream on cutaneous leishmaniasis in animal model

Leishmaniasis is a common disease endemic in some parts of Iran. Chemical or physical treatments or a combination of both are used for treatment of the disease. Nitric oxide [NO] is important for healing of leishmaniasis in human and animal. This study was designed to evaluate the benificial effects of a NO releasing cream on cutaneous leishmaniasis in an animal model. Balb/c mice were infected with Leishmania major by injecting promastigotes into the base of tails of mice to induce the lesion. Then the animals were divided into 3 groups [control, placebo and treatment]. Mice were treated with the drugs one time daily. The diameter of lesions were measured on days 0, 5, 10, 15, 20, 25 and 30 after the appearance of the lesions. Data were analyzed using one-way ANOVA test and p<0.05 considered as significant. The diameter of lesions were significantly reduced in 15, 20, 25 and 30 days in NO cream treated animals compared to control and placebo groups [P<0.05]. NO releasing compounds may be effective in the treatment of leishmaniasis