ABSTRACT
The main aim of this study was suggestion of a manual for group therapy based on cognitive behavioral therapy in opioid dependent patients co-morbid with major depressive disorder. In this semi-experimental research, 30 subjects were collected from some addiction treatment centers in Mashhad, north-eastern part of Iran. All of them gave opioid dependence and major depressive disorder via Structured Clinical Interview based on DSM-IV [SCID]. They were randomly allocated into control and experimental groups [each group included 15 subjects]. Beck Depression Inventory II and Morphine test were used at first and end of study. After 12 sessions in case group [control group did not receive cognitive-behavioral intervention] data were analyzed by%2 and U Mann-Whitney tests. The difference of relapse rate between experimental group and control group was statistically significant [P<0.001]. The depression rates in experimental and control groups showed significant decreases at the end of study [P<0.001]. Using group therapy with cognitive behavioral approach is effective in patients with co-morbidity of major depressive disorder and opioid dependency