[Evaluation of serum levels of interleukin-6 and -8 in patients with recurrent aphthous ulcerations]

Recurrent aphthous ulcers [RAU] are one of the most common ulcers in the oral cavity. Several studies have shown conflicting variations for inflammatory cytokines and other biologic markers in recurrent aphthous ulcers. The aim of the present study was to determine the level of IL-8 and IL-6 in the serum of patients with recurrent aphthous ulcers. In this case- control study, the serum levels of IL-8 and IL-6 were measured in patients with recurrent aphthous ulcers [n=40] and in healthy control subjects [n=40]. The cytokines levels were measured in the serum by ELISA. The data were analyzed with SPSS software using T- test. The mean value of the IL-8 and IL-6 in the patient group was 52.24 pg/ml and 9.39 pg/ml which were 10 and 4 times higher than that of the control group, respectively. The differences were statistically significant [p<0.01]. The results of the present study showed that the serum levels of IL-8 and IL-6 were elevated in the patient group, IL-8 level being more considerable

[Prevalence of pregnancy tumor in pregnant women]

Pregnancy tumor is a lesion affecting pregnant women between 3-9th months of pregnancy. This lesion often causes hemorrhage and sometimes pain, difficulty in eating, nutritional problems and anxiety. Prophylactic treatments during pregnancy are considered as preventive measures. Since there is a relationship between pregnancy tumor and level of oral hygiene, the frequency of this lesion varies in different populations. The aim of this study was to determine the prevalence of pregnancy tumors in women admitted to Kerman maternity hospitals. In this descriptive study, 745 pregnant women were examined. A questionnaire was designed to record the data including demographic characteristics, number of deliveries, oral hygiene and dental visits. An intraoral examination was done to find the pregnancy tumors. Student T-test, Chi-square and ANOVA test were used to compare the relationships between different variables. The results showed that pregnancy tumors were found in 31 [4.2%] pregnant women. The anterior maxillary gingiva was mostly affected, and most lesions [83.9%] bled easily during examination. There was a significant relationship between the use of dental floss and the number of yearly dental visits with the occurrence of pregnancy tumor [p<0.05]. Based on the results of this study and considering the role of periodontal disease on the well-being of the fetus, providing pregnant women with some information about the importance of oral hygiene during pregnancy is necessary. Adequate knowledge should be given to gynecologists and obstetrics and midwives in order to persuade them to refer their patients to dentists at the proper time for seeking preventive treatments and oral hygiene instruction

[Prevalence of orofacial complication among thalassemic patients in thalassemia center of Qazvin]

Thalassemia is the most common monogenic disorder of which Homozygote type [major-beta-thalassemia] is the most severe hemolytic anemia in Iran. Regarding the importance of orofacial complications in these patients and not having enough information about this disease in Iran, it's necessary to do a research in this point as well as knowing and reducing of orofacial complications of thalassemia. This descriptive [Case Series] study was done among all patients of Qazvin thalassemia center [110 patients]. Orofacial examinations [shape of face and nose, maxillary protrusion, oral paleness, delayed eruption of teeth, caries rate and type of occlusion] were done and their relation with medical treatment was evaluated. Statistical analysis was conducted by using SPSS software and Chi[2] test. The prevalence of orofacial complications are ranged as fallow: Saddle nose[71.08%], maxillary protrusion [55.5%], paleness of oral mucosa[48.2%], rodent face [30%], deep bite [28.2%], spaces between maxillary anterior teeth [22.7%], open bite [13.6%], delayed eruption of primary [10%] and permanent [8.2%] teeth. Prevalence of occlusion types were decreased as fallow: class I,II and III. Caries index [DMFT and dmft] was significantly more among the thalassemic patients than healthy peoples [P<0.05]. The prevalence of orofacial complications of thalassemia was very considerable. This study also showed the importance of early diagnosis and intensive medical treatment in reducing these complications

[Prevalence of orofacial complication among thalassemic patients in Thalassemia center of Qazvin]

Background: thalassemia is the most common monogenic disorder of which Homozygote type [major-beta-thalassemia] is the most severe hemolytic anemia in Iran. Regarding the importance of orofacial complications in these patients and not having enough information about this disease in Iran, it`s necessary to do a research in this point as well as knowing and reducing of orofacial complications of thalassemia

Materials and Methods: this descriptive [Case Series] study was done among all patients of Qazvin thalassemia center [110 patients]. Orofacial examinations [shape of face and nose, maxillary protrusion, oral paleness, delayed eruption of teeth, caries rate and type of occlusion] were done and their relation with medical treatment was evaluated. Statistical analysis was conducted by using SPSS software and x[2]test

Results: the prevalence of orofacial complications are ranged as fallow: Saddle nose [71.08%], maxillary protrusion [55.5%], paleness of oral mucosa [48.2%], rodent face [30%], deep bite [28.2%], spaces between maxillary anterior teeth [22.7%], open bite [13.6%], delayed eruption of primary [10%] and permanent [8.2%] teeth. Prevalence of occlusion types were decreased as fallow: class I, II and III. Caries index [DMFT and dmft] was significantly more among the thalassemic patients than healthy peoples [P<0.05]

Conclusions: the prevalence of orofacial complications of thalassemia was very considerable. This study also showed the importance of early diagnosis and intensive medical treatment in reducing these complications