ABSTRACT
Objective: The aim of this study is to see the frequency of vitamin D and its impact on the sample population
Study Design: Descriptive / cross sectional study
Place and Duration of Study: This study was conducted at Trauma and General Hospital, Karachi from January 2014 to June 2015
Materials and Methods: 205 patients were included in the study. Participants were assessed according to predesigned questionnaire. All patients were subjected to have complete blood count, serum calcium, phosphorous, albumin, alkaline phosphatase, SGPT, vitamin D and parathyroid hormone levels along with X-rays of hip joint and femur
Results: Out of total 205 patients, 12.7% were males and 87.3% were females. Mean age was 41.32 +/- 15.225 years. 5.9% had normal levels of Vitamin D[3], while 60.5%, 27% and 6.5% showed mild, moderate and severe deficiency. Serum calcium and phosphorous were deficient in 20.4% and 31.9% respectively. Serum alkaline phosphatase and parathyroid hormone were normal in most of the participants. The deficiency of Vitamin D[3] was mostly due to reduced sun exposure and excessive clothing [86.8%] while 8.3% showed malabsorption. This deficiency caused bone pains, and muscle pains in 55.6%, and 17.6% respectively. But none of the patient had any fracture
Conclusion: Levels of Vitamin D[3] are low in most of the people of Karachi but without any gross deformity. It is advisable to readdress the daily requirement of vitamin D bring the awareness among people regarding sun exposure and daily use of vitamin D supplements
ABSTRACT
Dapsone and other sulfonamides have been used successfully in the treatment of patients with a variety of blistering skin diseases. The patients most likely to respond to dapsone therapy have predominantly neutrophilic infiltrate in their skin e.g. dermatitis herpetiformis and linear IgA disease. The precise mechanism of action of dapsone is unknown. In vitro studies have shown that dapsone can interfere with the production of and response to neutrophilic chemotactants and that it may impair the neutrophils' ability to localize to sites of inflammation and produce toxic oxygen intermediates. The safe use of dapsone requires an understanding of the pharmacology and adverse effects of the drug. Hemolytic anemia and methemoglobinemia are two of the dose-related adverse effects. Agranulocytosis, motor neuropathy, and dapsone hypersensitivity syndrome are some of the severe idiosyncratic effects that can occur in patients treated with dapsone. Careful patient selection and close monitoring of patients during therapy with dapsone are critical elements in the safe and effective use of dapsone for patients with blistering skin diseases